Hydroxyl radical formation following methamphetamine administration to rats
Hydroxyl radical formation following methamphetamine administration to rats
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DOI：
10.1111/j.1600-0773.1999.tb00080.x
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发表时间：
1999-09-01
期刊：
影响因子：
--
通讯作者：
Nakashima, T
中科院分区：
文献类型：
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作者：
Kita, T;Takahashi, M;Nakashima, T
给予神经毒性剂量的甲基苯丙胺（8 mg/kg，腹腔注射x 4次，间隔2小时）导致纹状体中多巴胺和3,4-二羟基苯基乙酸显著减少，纹状体中3-甲氧基酪胺水平升高，纹状体和海马中血清素和5-羟基吲哚乙酸水平降低。此外，甲基苯丙胺处理引起大鼠直肠温度升高。最后一次注射甲基苯丙胺105分钟后，脑室内注射水杨酸，纹状体和海马中2,3-和2,5-二羟基苯甲酸增加。此外，2,3-二羟基苯甲酸与水杨酸的比值在纹状体中显著增加，而在海马中没有。这些结果表明羟基自由基可能在甲基苯丙胺诱导的纹状体神经毒性中起重要作用，其形成可能是甲基苯丙胺诱导的多巴胺释放的结果。
Administration of neurotoxic doses of methamphetamine (8 mg/kg, intraperitoneally x 4 times, at 2 hr intervals) caused a significant decrease in dopamine and 3,4-dihydroxyphenylacetic acid and an increase in 3-methoxytyramine levels in the striatum along with a decrease in serotonin and 5-hydroxyindoleacetic acid levels in the striatum and hippocampus. In addition, the methamphetamine treatment caused an increase in rat rectal temperature. Intraventricular injection of salicylate 105 min. after the last injection of methamphetamine produced an increase in 2,3- and 2,5-dihydroxybenzoic acid in the striatum and hippocampus. Moreover, the ratio of 2,3-dihydroxybenzoic acid to salicylate was significantly increased in the striatum, but not in the hippocampus. These results indicate that the hydroxyl radical may play an important role in methamphetamine-induced neurotoxicity in rat striatum and that its formation may be the result of methamphetamine-induced release of dopamine.