Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
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DOI：
10.1161/hypertensionaha.107.103523
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发表时间：
2008-03
期刊：
影响因子：
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通讯作者：
Ahluwalia A
中科院分区：
文献类型：
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作者：
Webb AJ;Patel N;Loukogeorgakis S;Okorie M;Aboud Z;Misra S;Rashid R;Miall P;Deanfield J;Benjamin N;MacAllister R;Hobbs AJ;Ahluwalia A
富含水果和蔬菜的饮食可以降低血压（BP）和不良心血管事件的风险。然而，这种效应的机制尚未阐明。某些蔬菜具有高硝酸盐含量，我们假设这可能代表了通过生物活化的血管保护性一氧化氮的来源。在健康志愿者中，摄入膳食硝酸盐负荷（甜菜根汁500 ml）后约3小时，血压显著降低（Δmax - 10.4/8 mmHg）;该效应与血浆亚硝酸盐浓度的峰值增加相关。膳食硝酸盐负荷也防止了由人前臂急性缺血损伤引起的内皮功能障碍，并显着减弱了胶原蛋白和ADP引起的离体血小板聚集。中断肠唾液硝酸盐转化为亚硝酸盐（由位于舌头表面的细菌厌氧菌促进），防止血浆亚硝酸盐的上升，阻止血压下降，并取消对血小板聚集的抑制作用，证实这些血管保护作用是由于从摄入的硝酸盐转化为亚硝酸盐的活性。这些发现表明，膳食硝酸盐是富含蔬菜饮食的有益效果的基础，并突出了治疗心血管疾病的“天然”，低成本方法的潜力。
Diets rich in fruits and vegetables reduce blood pressure (BP) and the risk of adverse cardiovascular events. However, the mechanisms of this effect have not been elucidated. Certain vegetables possess a high nitrate content and we hypothesized that this might represent a source of vasoprotective nitric oxide via bioactivation. In healthy volunteers, approximately 3h following ingestion of a dietary nitrate load (beetroot juice 500ml) BP was substantially reduced (Δmax - 10.4/8 mmHg); an effect that correlated with peak increases in plasma nitrite concentration. The dietary nitrate load also prevented endothelial dysfunction induced by an acute ischemic insult in the human forearm and significantly attenuated ex vivo platelet aggregation in response to collagen and ADP. Interruption of the enterosalivary conversion of nitrate to nitrite (facilitated by bacterial anaerobes situated on the surface of the tongue), prevented the rise in plasma nitrite, blocked the decrease in BP and abolished the inhibitory effects on platelet aggregation, confirming that these vasoprotective effects were due to the activity of nitrite converted from the ingested nitrate. These findings suggest that dietary nitrate underlies the beneficial effects of a vegetable-rich diet and highlights the potential of a ‘natural’, low cost approach for the treatment of cardiovascular disease.