Use of the Collagen Gel Droplet Embedded Drug Sensitivity Test to Determine Drug Sensitivity against Ovarian Mature Cystic Teratoma with Malignant Transformation to Adenocarcinoma: A Case Report
Use of the Collagen Gel Droplet Embedded Drug Sensitivity Test to Determine Drug Sensitivity against Ovarian Mature Cystic Teratoma with Malignant Transformation to Adenocarcinoma: A Case Report
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DOI：
10.1159/000099985
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发表时间：
2007-02
期刊：
影响因子：
3.3
通讯作者：
W. Yamagami;K. Banno;M. Kawaguchi;Megumi Yanokura;Yoshiko Kuwabara;N. Hirao;N. Susumu;K. Tsukazaki;D. Aoki
中科院分区：
文献类型：
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作者：
W. Yamagami;K. Banno;M. Kawaguchi;Megumi Yanokura;Yoshiko Kuwabara;N. Hirao;N. Susumu;K. Tsukazaki;D. Aoki
背景：胶原凝胶液滴嵌入药物敏感性试验（CD-DST）是一种仅需要少量细胞的新型抗癌药物敏感性试验。我们报告了该测试在辅助化疗选择中的应用，该病例用于治疗涉及卵巢成熟囊性畸胎瘤恶变的罕见卵巢癌病例。病例报告：患者为70岁女性，患有卵巢肿瘤、胸腔积液、癌性腹水、胸壁肿瘤。组织病理学诊断为腺癌，成熟囊性畸胎瘤恶变，IV期。根据 CD-DST 结果选择紫杉醇/卡铂治疗作为辅助化疗。 6个疗程结束后，癌性腹水未见明显增加，病灶未复发，胸壁肿瘤完全消失。结论：CD-DST对于原发肿瘤组织学类型未知的卵巢癌患者术前化疗药物的选择可能特别有用。
Background: The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ovarian mature cystic teratoma. Case Report: The patient was a 70-year-old female with an ovarian tumor, pleural effusion, carcinomatous ascites and a chest wall tumor. The histopathological diagnosis was adenocarcinoma, mature cystic teratoma with malignant transformation, stage IV. Paclitaxel/carboplatin therapy was selected as adjuvant chemotherapy based on CD-DST results. Upon completion of 6 courses, no increases in carcinomatous ascites or recurrent lesions were evident, and the chest wall tumor had disappeared completely. Conclusion: The CD-DST may be particularly useful for selecting preoperative chemotherapeutic drugs for patients with ovarian cancer in which the histological type of the primary tumor is unknown.