CIRCADIAN PERIOD IN MICE - ANALYSIS OF GENETIC AND MATERNAL CONTRIBUTIONS TO INBRED STRAIN DIFFERENCES
CIRCADIAN PERIOD IN MICE - ANALYSIS OF GENETIC AND MATERNAL CONTRIBUTIONS TO INBRED STRAIN DIFFERENCES
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DOI：
10.1007/bf01067080
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发表时间：
1988-01-01
影响因子：
2.6
通讯作者：
STEPHAN, FK
中科院分区：
文献类型：
--
作者：
POSSIDENTE, B;STEPHAN, FK
观察到四个近交系小鼠(Mus Musculus)轮子跑活动的昼夜节律的自由跑周期约有25分钟的差异。两个品系的正反交组合，其中一个组合的昼夜节律接近中间值，而另一个组合的显性周期较短。这两组杂交都没有显示出母体对昼夜节律有显著影响的证据。这些结果表明，近交系在昼夜节律上的差异最初是由品系间等位基因差异的直接影响造成的，而不是通过母体介导的机制。
Differences of approximately 25 min in the free-running period of a circadian rhythm for wheel-running activity were observed among four inbred mouse strains (Mus musculus). Two sets of reciprocal hybrid crosses among the strains showed approximately intermediate values for circadian period in one cross and dominance for a short period in the other. Neither set of crosses showed evidence of significant maternal effects on circadian period. These results indicate that the inbred strain differences in circadian period are imposed primiarily by direct effects of allelic differences among the strains, rather than through maternally mediated mechanisms.