The innate immune response to HIV-1: to sense or not to sense.
The innate immune response to HIV-1: to sense or not to sense.
复制标题
对 HIV-1 的先天免疫反应：感知或不感知。
DOI：
10.1089/dna.2014.2378
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发表时间：
2014
影响因子：
3.1
通讯作者：
Landau,NathanielR
中科院分区：
文献类型：
--
作者：
Landau,NathanielR
对病毒的免疫反应提供了一种快速警告宿主入侵者存在的手段，激活了一系列内在和适应性抗病毒机制。几个研究小组在理解对HIV-1的先天免疫反应方面取得了进展，尽管他们的发现有所不同。一些研究人员发现，病毒在模式识别受体的雷达下滑动，模式识别受体通过选择限制病毒核酸可及性的宿主因子来感知病毒，而其他人则发现病毒被感知并激活I型干扰素反应。本文回顾了最近的研究结果，并讨论了相似性和差异。
The immune responses to viruses provide a means to quickly alert the host to the presence of an invader, activating a range of intrinsic and adaptive antiviral mechanisms. Several research groups have made advances in understanding the innate immune response to HIV-1, although their findings differ. Some investigators find that the virus slips under the radar of the pattern recognition receptors that sense viruses by co-opting host factors that restrict accessibility of the viral nucleic acids, while others find that the virus is sensed and activates a type-I interferon response. This article reviews the recent findings and discusses the similarities and differences.