Drug eruption induced by cyanamide (carbimide): a clinical and histopathologic study of 7 patients.
Drug eruption induced by cyanamide (carbimide): a clinical and histopathologic study of 7 patients.
复制标题
氰胺（碳酰亚胺）引起的药疹：7 例患者的临床和组织病理学研究。
作者：
S. Kawana
背景
在一些国家，氰胺被用作酒精摄入抑制剂，几乎没有有害的副作用。迄今已报告3例过敏性接触性皮炎，仅1例因氰胺引起的苔藓样药疹。
目标和方法
我们描述7例单氰胺所致药疹的临床表现、病程、组织病理学和免疫组织化学检查结果。
结果
7 名患者中，6 名出现剥脱性皮炎，1 名出现扁平苔藓样皮疹。 3例剥脱性皮炎患者表现为高热、剧烈瘙痒、厌食、失眠和全身不适，提示过敏反应的诊断。在所有病例中，组织病理学观察到真皮上层有单核细胞浸润，具有亲表皮性和表皮细胞角化不良。浸润细胞主要由T4阳性淋巴细胞组成。
结论
氰胺引起的皮肤反应可能属于苔藓样药疹范围，其发生率可能比以前报道的要高得多。
BACKGROUND
In some countries, cyanamide is used as an alcohol intake inhibitor with few harmful side effects. So far 3 cases of allergic contact dermatitis and only 1 of lichenoid drug eruption due to cyanamide have been reported.
OBJECTIVES AND METHODS
We describe the clinical manifestations, course, histopathologic and immunohistochemical findings of 7 cases of cyanamide-induced drug eruption.
RESULTS
Of the 7 patients, 6 developed exfoliative dermatitis and 1 a lichen-planus-like eruption. Three patients with exfoliative dermatitis showed high fever, severe itching, anorexia, insomnia and general malaise, suggesting the diagnosis of hypersensitivity reaction. In all cases, mononuclear cell infiltration in the upper dermis with epidermotropism and dyskeratosis of the epidermal cells were observed histopathologically. The infiltrating cells consisted mainly of T4-positive lymphocytes.
CONCLUSION
The cyanamide-induced skin reaction may be included in the spectrum of lichenoid drug eruptions, and its incidence may be much higher than previously reported.