DETERMINATION OF THE OPTIMAL RATIO OF LINOLEIC-ACID TO ALPHA-LINOLENIC ACID IN INFANT FORMULAS
DETERMINATION OF THE OPTIMAL RATIO OF LINOLEIC-ACID TO ALPHA-LINOLENIC ACID IN INFANT FORMULAS
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DOI：
10.1016/s0022-3476(05)81250-8
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发表时间：
1992-04-01
影响因子：
5.1
通讯作者：
GIBSON, RA
中科院分区：
文献类型：
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作者：
CLARK, KJ;MAKRIDES, M;GIBSON, RA
在喂食具有高比例亚油酸（18：2n-6）（LA）与α-亚麻酸（18：3 n-3）（ALA）的市售婴儿配方食品后10周，从一组足月婴儿中采集的红细胞总脂质的脂肪酸组成（19：1，LA为14%，ALA为0.7%，A组，n = 10）与来自喂食含有LA/LA的配方食品的婴儿的红细胞的脂肪酸组成进行比较。增加ALA（4：1; LA，13%; ALA，3.3%; B组，n = 11）或降低LA（3：1; LA，3.5%; ALA，1.1%; C组，n = 8）可降低ALA比率。结果与母乳喂养婴儿的年龄对照组（n = 9）进行了比较。相对于配方A（5.97% +/-0.76%; p < 0.05），降低LA/ALA比率增加了n-3 C20和C22脂肪酸掺入（配方B = 8.98%+/-0.65%;配方C = 9.30% +/-0.95%）。尽管相对于配方A（3.47% +/- 0.46%; p < 0.05），配方B和C（4.78% +/- 0.45%和4.48% +/-0.49%）喂养的婴儿的二十二碳六烯酸（22：6 n-3）（DHA）掺入量最高，但其未达到母乳喂养的婴儿的水平（6.55% +/- 1.23%; p < 0.05）。此外，所有配方奶粉喂养组的花生四烯酸（20：4 n-6）（AA）水平均低于母乳喂养组（p < 0.05）。基于一些方程，预测喂食较低LA/ALA比率的婴儿的组织中AA水平将进一步降低。由于AA和DHA可能对婴儿的正常神经发育至关重要，LA/ALA比例低于4：1的配方奶粉可能导致脂肪酸谱与母乳喂养的婴儿明显不同。
The fatty acid composition of erythrocyte total lipids taken from a group of term infants 10 weeks after being fed a commercial infant formula with a high ratio of linoleic acid (18:2n-6) (LA) to alpha-linolenic acid (18:3n-3) (ALA) (19:1; LA, 14%; ALA, 0.7%; group A, n = 10) was compared with the fatty acid composition of erythrocytes from infants fed formulas that contained LA/ALA ratios reduced by either increasing ALA (4:1; LA, 13%; ALA, 3.3%; group B, n = 11) or decreasing LA (3:1; LA, 3.5%; ALA, 1.1%; group C, n = 8). Results were compared with those in an age-controlled group (n = 9) of breast-fed infants. Decreasing the LA/ALA ratio increased n-3 C20 and C22 fatty acid incorporation (formula B = 8.98% +/- 0.65%; formula C = 9.30% +/- 0.95%) relative to formula A (5.97% +/- 0.76%; p < 0.05). Although docosahexaenoic acid (22:6n-3) (DHA) incorporation was highest in infants fed formulas B and C (4.78% +/- 0.45% and 4.48% +/- 0.49%, respectively) relative to formula A (3.47% +/- 0.46%; p < 0.05), it did not reach levels found in breast-fed infants (6.55% +/- 1.23%; p < 0.05). In addition, levels of arachidonic acid (20:4n-6) (AA) were lower in all formula-fed groups (p < 0.05) relative to those in breast-fed infants. Based on some equations, it is predicted that AA levels in tissues of infants fed lower LA/ALA ratios would be reduced even further. Because both AA and DHA are probably essential for normal neural development of the infant, formulas with LA/ALA ratios below 4:1 are likely to result in fatty acid profiles notably different from those of breast-fed infants.