Lymphoplasmacytic Infiltrate of Regional Lymph Nodes in Küttner's Tumor (Chronic Sclerosing Sialadenitis): A Report of 3 Cases
Lymphoplasmacytic Infiltrate of Regional Lymph Nodes in Küttner's Tumor (Chronic Sclerosing Sialadenitis): A Report of 3 Cases
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库特纳瘤（慢性硬化性唾液腺炎）局部淋巴结淋巴浆细胞浸润3例报告
DOI：
10.1177/1066896907306969
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发表时间：
2008
影响因子：
1.2
通讯作者：
S. Nakamura
中科院分区：
文献类型：
--
作者：
M. Kojima;S. Miyawaki;S. Takada;K. Kashiwabara;T. Igarashi;S. Nakamura
3例Küttner瘤局部淋巴结表现为反应性滤泡增生和滤泡间浆细胞增多。患者分别为71岁、57岁和73岁的日本男性。浆细胞的多型性通过免疫组织化学证实。有大量IgG阳性浆细胞，散在IgA阳性或IgM阳性浆细胞。IgG 4阳性细胞占IgG阳性浆细胞的25%至40%。2例实验室检查显示多克隆高免疫球蛋白血症。1例患者血清IgG 4水平升高（16%）。本3例表明，Küttner瘤的区域淋巴结可能表现为反应性滤泡增生和明显的滤泡间浆细胞增多，应与各种良性和恶性淋巴组织增生性疾病（包括系统性风湿病、浆细胞型Castleman病和表现出明显浆细胞分化的粘膜相关淋巴组织型边缘B细胞淋巴瘤的淋巴结受累）相鉴别。
Regional lymph nodes of Küttner's tumor from 3 patients showed reactive follicular hyperplasia and prominent interfollicular plasmacytosis. The patients were 71-, 57-, and 73-year-old Japanese men. The polytypic nature of plasma cells was demonstrated by immunohistochemistry. There were numerous IgG-positive plasma cells with scattered IgA-positive or IgM-positive plasma cells. IgG4-positive cells comprised 25% to 40% of IgG-positive plasma cells. Prominent polyclonal hyperimmunoglobulinemia was demonstrated on laboratory test in 2 cases examined. An elevated serum IgG4 level (16%) was also demonstrated in 1 patient. The present 3 cases indicated that regional lymph node of Küttner's tumor may show reactive follicular hyperplasia and prominent interfollicular plasmacytosis and should be differentiated from various benign and malignant lymphoproliferative disorders including systemic rheumatic disease, plasma cell type of Castleman disease, and lymph node involvement of marginal B-cell lymphoma of the mucosa-associated lymphoid tissue type showing prominent plasma cell differentiation.
影响因子：
5.6
作者：
Kitagawa, S;Zen, Y;Nakanuma, Y
通讯作者：
Nakanuma, Y