Prediction scores based on neonatal inflammatory markers for chorioamnionitis and funisitis in extremely low gestational age neonates
Prediction scores based on neonatal inflammatory markers for chorioamnionitis and funisitis in extremely low gestational age neonates
复制标题
基于新生儿炎症标志物的极低胎龄新生儿绒毛膜羊膜炎和绳索炎的预测评分
DOI：
10.1111/apa.16701
复制
发表时间：
2023
期刊：
影响因子：
3.8
通讯作者：
Nakamura Kimitoshi
中科院分区：
文献类型：
--
作者：
Yoshimatsu Hidetaka;Iwai Masanori;Kitabatake Yasuji;Ozono Keiichi;Nakamura Kimitoshi
AimThe aim of the study was to examine the predictive value of inflammatory marker for choriocellulitis and funisitis in extremely low gestational age newborns.MethodsAccording to the Redline histopathological classification，extremely low gestational age newborns classified into：（1）母体炎症反应≤1或≥2，基于胎盘炎症结果，和（2）胎儿炎症反应≤1或≥2，根据脐带的炎症发现在入院时和出生后12-36 h，比较降钙素原和高敏C反应蛋白水平以及白色血细胞和中性粒细胞计数。对于产妇和胎儿的炎症反应≥2，每个炎症标志物的预测值calculated.ResultsOn入院，降钙素原有最好的预测值为产妇和胎儿的炎症反应≥2。母体炎症反应≥2预测评分包括入院时的降钙素原水平、出生后12-36 h的高敏C反应蛋白水平和白色血细胞计数。胎儿炎症反应≥2预测评分包括入院时和出生后12-36 h的降钙素原水平和白色血细胞计数。结论降钙素原、超敏C反应蛋白水平和白色血细胞计数是极低胎龄新生儿绒毛膜炎和脐带炎的高度敏感预测指标。
AimThe aim of the study was to examine the predictive value of inflammatory markers for chorioamnionitis and funisitis in extremely low gestational age neonates.MethodsAccording to the Redline histopathological classification, extremely low gestational age neonates were classified into: (1) maternal inflammatory response ≤1 or ≥2, based on inflammatory findings of the placenta and (2) foetal inflammatory response ≤1 or ≥2, based on inflammatory findings of the umbilical cord. On admission and 12–36 h postnatally, procalcitonin and high‐sensitivity C‐reactive protein levels and white blood cell and neutrophil counts were compared. For both maternal and foetal inflammatory responses ≥2, the predictive value of each inflammatory marker was calculated.ResultsOn admission, procalcitonin had the best predictive value for maternal and foetal inflammatory response ≥2. The maternal inflammatory response ≥2 prediction score includes procalcitonin level on admission, high‐sensitivity C‐reactive protein level and white blood cell count at 12–36 h postnatally. Foetal inflammatory response ≥2 prediction score includes procalcitonin level and white blood cell count on admission and 12–36 h postnatally. The sensitivities were 96.4% and 96.3%, respectively.ConclusionProcalcitonin, high‐sensitivity C‐reactive protein levels and white blood cell count provide highly sensitive prediction scores for chorioamnionitis and funisitis in extremely low gestational age neonates.