Improving the performance of phase-change perfluorocarbon droplets for medical ultrasonography: current progress, challenges, and prospects.
Improving the performance of phase-change perfluorocarbon droplets for medical ultrasonography: current progress, challenges, and prospects.
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作者：
Sheeran PS;Dayton PA
在过去的二十年中，已经研究了全氟化合物（PFC）的液滴，用于跨多种成像方式的生物医学应用。可以在超声波领域从液体转换为气体，相变的液滴是许多传统微泡剂的替代品诊断和治疗应用。为了提高超声治疗应用的效率，并在诊断和分子成像中实现了意外的应用。
Over the past two decades, perfluorocarbon (PFC) droplets have been investigated for biomedical applications across a wide range of imaging modalities. More recently, interest has increased in “phase-change” PFC droplets (or “phase-change” contrast agents), which can convert from liquid to gas with an external energy input. In the field of ultrasound, phase-change droplets present an attractive alternative to traditional microbubble agents for many diagnostic and therapeutic applications. Despite the progress, phase-change PFC droplets remain far from clinical implementation due to a number of challenges. In this review, we survey our recent work to enhance the performance of phase-change agents for ultrasound through a variety of techniques in order to provide increased efficacy in therapeutic applications of ultrasound and enable previously unexplored applications in diagnostic and molecular imaging.