RESULTS OF A RANDOMIZED CLINICAL-TRIAL COMPARING 2 RADIATION SCHEDULES IN THE PALLIATIVE TREATMENT OF BRAIN METASTASES
RESULTS OF A RANDOMIZED CLINICAL-TRIAL COMPARING 2 RADIATION SCHEDULES IN THE PALLIATIVE TREATMENT OF BRAIN METASTASES
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DOI：
10.1016/0167-8140(93)90091-l
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发表时间：
1993-02-01
影响因子：
5.7
通讯作者：
ARRIAGADA, R
中科院分区：
文献类型：
--
作者：
HAIEMEDER, C;PELLAECOSSET, B;ARRIAGADA, R
在216例脑转移瘤患者中，在一项随机试验中比较了两种脑放射治疗方案：一个疗程18戈伊/3次/3天与相同的分割，然后进行第二个疗程的放射治疗，间隔一个月。第二疗程与第一疗程相同或25戈伊/10次/14天。两组的总生存率、神经系统反应或并发症发生率均无差异。两个临床因素似乎是预后的总生存率：存在多个脑转移和脑外转移的存在。
In 216 patients with brain metastases two schedules of brain irradiation were compared in a randomized trial: one course of 18 Gy/3 fractions/3 days versus the same fractionation followed by a second course of radiotherapy with a one-month time interval. The second course was identical to the first one or delivered 25 Gy/10 fractions/14 days. No difference in overall survival, nor in the neurologic response or in the incidence of complications was demonstrated. Two clinical factors appeared to be prognostic of the overall survival: the presence of multiple brain metastases and the presence of extracerebral metastases.