More highly myelinated white matter tracts are associated with faster processing speed in healthy adults
More highly myelinated white matter tracts are associated with faster processing speed in healthy adults
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DOI：
10.1016/j.neuroimage.2017.12.069
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发表时间：
2018-05-01
期刊：
影响因子：
5.7
通讯作者：
Cherbuin, Nicolas
中科院分区：
文献类型：
--
作者：
Chopra, Sidhant;Shaw, Marnie;Cherbuin, Nicolas
本研究的目的是调查白质束的估计髓磷脂含量是否可以预测认知处理速度以及这种关联是否受到年龄的调节。对 570 名社区生活个体（277 名中年人，293 名老年人）的估计髓磷脂含量和处理速度之间的关联进行了评估。使用平均 T1w/T2w 磁共振比估计体内六个白质束（前放射冠、上放射冠、脑桥交叉束、内囊前肢、胼胝体膝部和胼胝体压部）的髓磷脂含量。通过从 5 个单独的处理速度测试中提取主成分来估计处理速度。结果发现，即使在控制了社会人口统计、健康和遗传变量并校正多重比较之后，内囊双侧前肢和胼胝体左侧压部的估计髓磷脂含量也是处理速度的重要预测因子。内囊前肢的估计髓磷脂含量高 1 个 SD 与处理速度加快 2.53% 相关，而胼胝体左侧压部的处理速度则加快 2.20%。此外，在所有六个白质束中都发现中年和老年参与者之间估计的髓磷脂含量存在显着差异。目前的结果表明，使用神经成像方法在健康老年人体内估计的髓磷脂含量足以精确地预测行为测量中处理速度的变化。
The objective of this study was to investigate whether the estimated myelin content of white matter tracts is predictive of cognitive processing speed and whether such associations are modulated by age. Associations between estimated myelin content and processing speed were assessed in 570 community-living individuals (277 middle-age, 293 older-age). Myelin content was estimated in-vivo using the mean T1w/T2w magnetic resonance ratio, in six white matter tracts (anterior corona radiata, superior corona radiata, pontine crossing tract, anterior limb of the internal capsule, genu of the corpus callosum, and splenium of the corpus callosum). Processing speed was estimated by extracting a principal component from 5 separate tests of processing speed. It was found that estimated myelin content of the bilateral anterior limb of the internal capsule and left splenium of the corpus callosum were significant predictors of processing speed, even after controlling for socio-demographic, health and genetic variables and correcting for multiple comparisons. One SD higher in the estimated myelin content of the anterior limb of the internal capsule was associated with 2.53% faster processing speed and within the left splenium of the corpus callosum with 2.20% faster processing speed. In addition, significant differences in estimated myelin content between middle-age and older participants were found in all six white matter tracts. The present results indicate that myelin content, estimated in vivo using a neuroimaging approach in healthy older adults, is sufficiently precise to predict variability in processing speed in behavioural measures.