Myeloid-derived suppressor cells in transplantation: the dawn of cell therapy.

Myeloid-derived suppressor cells in transplantation: the dawn of cell therapy.
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骨髓源性抑制细胞移植:细胞治疗的黎明

DOI:
10.1186/s12967-018-1395-9
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发表时间:
2018-01-29
影响因子:
7.4
通讯作者:
Xu M
Xu M
中科院分区:
医学2区
文献类型:
--
作者:
Zhang W;Li J;Qi G;Tu G;Yang C;Xu M

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骨髓源性抑制细胞(MDSC)是一系列在抑制T细胞相关反应中起重要作用的先天性细胞。这种异质的未成熟细胞群参与肿瘤免疫。近年来,MDSCs在移植免疫耐受中的作用越来越受到人们的重视,成为移植免疫学研究的一个重要领域。在这篇综述中,我们总结了最近的研究MDSCs在不同类型的移植。本文还重点介绍了免疫抑制剂对MDSCs的影响以及该领域的研究障碍和未来的研究方向。
Myeloid-derived suppressor cells (MDSCs) are a series of innate cells that play a significant role in inhibiting T cell-related responses. This heterogeneous population of immature cells is involved in tumor immunity. Recently, the function and importance of MDSCs in transplantation have garnered the attention of scientists and have become an important focus of transplantation immunology research because MDSCs play a key role in establishing immune tolerance in transplantation. In this review, we summarize recent studies of MDSCs in different types of transplantation. We also focus on the influence of immunosuppressive drugs on MDSCs as well as future obstacles and research directions in this field.
DOI: 10.1371/journal.pone.0100013
发表时间: 2014
期刊: PloS one
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