U-shaped relationship between serum uric acid level and decline in renal function during a 10-year period in female subjects: BOREAS-CKD2
U-shaped relationship between serum uric acid level and decline in renal function during a 10-year period in female subjects: BOREAS-CKD2
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DOI：
10.1038/s41440-020-0532-z
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发表时间：
2020-08-13
影响因子：
5.4
通讯作者：
Miura, Tetsuji
中科院分区：
文献类型：
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作者：
Mori, Kazuma;Furuhashi, Masato;Miura, Tetsuji
虽然高尿酸血症被认为是慢性肾脏病（CKD）的危险因素，但低血清尿酸（UA）受试者的CKD风险仍存在争议。在这里，我们研究了CKD风险与血清UA水平的相关性是否因一般人群中受试者的性别和年龄而异。在接受年度健康检查的受试者中，我们入组了6，779例受试者（男性/女性：4，454/2，325;年龄：45 ± 9岁），数据来自10年随访，排除了基线时服用抗高尿酸血症药物的受试者和CKD受试者。在随访期间，11.4%的男性和11.7%的女性发展为CKD。一个显着的性别，而不是年龄的相互作用，与基线UA水平对CKD的风险的影响被发现。一个限制性的三次样条分析显示，在女性的基线UA水平与CKD的风险呈U形关联。女性多变量考克斯比例风险分析显示，第五个五分位数（Q5，>= 5 mg/dL; HR：1.68）和第一个五分位数（Q1，
While hyperuricemia is recognized as a risk factor for chronic kidney disease (CKD), the risk of CKD in subjects with a low level of serum uric acid (UA) remains controversial. Here, we examined whether the association of CKD risk with serum UA level differs depending on the sex and age of subjects in a general population. Of subjects who received annual health checkups, we enrolled 6,779 subjects (male/female: 4,454/2,325; age: 45 +/- 9 years) with data from a 10-year follow-up after excluding subjects taking anti-hyperuricemic drugs and those with CKD at baseline. During the follow-up period, 11.4% of the males and 11.7% of the females developed CKD. A significant interaction of sex, but not age, with the effect of baseline UA level on CKD risk was found. A restricted cubic spline analysis showed a U-shaped association of the baseline UA level with the risk of CKD in females. Multivariable Cox proportional hazard analyses for females showed that baseline UA levels in the 5th quintile (Q5, >= 5 mg/dL; HR: 1.68) and the 1st quintile (Q1,