Steroidal saponins from the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells
Steroidal saponins from the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells
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DOI：
10.1016/s0031-9422(98)00036-3
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发表时间：
1998-06-01
期刊：
影响因子：
3.8
通讯作者：
Sashida, Y
中科院分区：
文献类型：
--
作者：
Mimaki, Y;Kuroda, M;Sashida, Y
对假叶树的地下部分进行了植物化学研究，作为百合科植物系统研究的一部分。分离得到6个新的螺甾皂苷和5个新的呋甾皂苷，并通过波谱分析（包括二维核磁共振技术）和水解方法对其结构进行了归属。具有三个乙酰基连接到内部半乳糖基部分的鲁斯科苷元二苷及其相应的26-葡萄糖基氧呋甾醇皂苷对白血病HL-60细胞具有细胞抑制活性。(C)1998爱思唯尔科技有限公司版权所有。
Phytochemical examination of the underground parts of Ruscus aculeatus has been undertaken as part of a systematic study of plants of the Liliaceae. Six new spirostanol saponins and five new furostanol saponins were isolated, and their structures were assigned on the basis of spectroscopic analysis, including two-dimensional NMR techniques, and hydrolysis. Ruscogenin diglycoside with three acetyl groups attached to the inner galactosyl moiety and its corresponding 26-glucosyloxyfurostanol saponin showed cytostatic activity on leukemia HL-60 cells. (C) 1998 Elsevier Science Ltd. All rights reserved.