Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model
Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model
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DOI：
10.1016/j.jff.2014.08.002
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发表时间：
2014-09
影响因子：
5.6
通讯作者：
Liqing Zang;Yasuhito Shimada;Jumpei Kawajiri;Toshio Tanaka;Norihiro Nishimura
中科院分区：
文献类型：
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作者：
Liqing Zang;Yasuhito Shimada;Jumpei Kawajiri;Toshio Tanaka;Norihiro Nishimura
研究了柚子皮、柚子果渣正己烷提取物和桔红素对斑马鱼代谢紊乱的影响。所有测试的材料都表现出抗肥胖作用。柚子皮显著抑制血浆三酰甘油（TG）和肝脏脂质积累的上升。柚子皮可显著上调肝脏过氧化物酶体增殖物激活受体（peroxisome proliferator-activated receptor，alpha B）及其靶基因的mRNA表达，提示柚子皮可增强肝脏脂肪酸β-氧化。在内脏脂肪组织中，柚子皮显著增加了在脂肪分化和维持中起作用的过氧化物酶体增殖物激活受体（PPARG，gamma）和脂联素（adiponectin，C1 Q and collagen domain containing，B）的mRNA表达。结果提示，柚子皮通过激活肝脏和脂肪细胞的PPARα和PPARγ通路发挥抗肥胖作用。此外，柚子果渣的抗肥胖作用提出了一种新的应用，以实现完全利用柚子，而不是作为工业废物处理。
Effects of yuzu peel (Citrus junosSiebold ex Tanaka), yuzu pomace after hexane extraction, and auraptene on metabolic disorders in zebrafish with diet-induced obesity (DIO) were evaluated. All materials tested exhibited anti-obesity effects. Yuzu peel significantly suppressed the rise in plasma triacylglycerol (TG) and liver lipid accumulation. The hepatic mRNA expression ofpparab(peroxisome proliferator-activated receptor, alpha b) and its target genes were significantly upregulated by yuzu peel, which suggests enhanced fatty acid β-oxidation in liver. In visceral adipose tissue, yuzu peel significantly increased the mRNA expression ofpparg(peroxisome proliferator-activated receptor, gamma) andadipoqb(adiponectin, C1Q and collagen domain containing, b), which play roles in adipose differentiation and maintenance. Our findings suggest that yuzu peel exerts anti-obesity effects by activating hepatic PPARα and adipocyte PPARγ pathways. Additionally, the anti-obesity effects of yuzu pomace suggest a novel application to achieve complete use of yuzu instead of disposal as industrial waste.