Interleukin-1β+3953 allele 2:: association with disease status in adult periodontitis
Interleukin-1β+3953 allele 2:: association with disease status in adult periodontitis
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DOI：
10.1111/j.1600-051x.1998.tb02370.x
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发表时间：
1998-10-01
影响因子：
6.7
通讯作者：
Galbraith, GMP
中科院分区：
文献类型：
--
作者：
Gore, EA;Sanders, JJ;Galbraith, GMP
成人牙周炎是一种复杂的多因素疾病，其病因尚未明确。白介素1β(IL-1β)的促炎和骨吸收特性强烈提示该细胞因子在牙周病发病机制中的作用。在本文报道的研究中，与早、中度牙周炎患者相比，晚期成人牙周炎患者IL-1β基因频率显著增加，包括IL-1β(+3953)限制性片段长度双等位基因多态的等位基因2。此外，等位基因2与晚期疾病患者激活的外周血多形核细胞产生IL-1β的增加有关，尽管这种增加没有达到统计学意义。结果显示，IL-1β(+3953)多态的等位基因2和双等位基因LL-1α(-889)的等位基因2在两组患者和口腔健康对照组之间存在显著的连锁不平衡。这些发现为IL-1α和β基因多态性在成人牙周炎易感性中的可能作用提供了新的见解。
Adult periodontitis is a complex multifactorial disease whose etiology is not well defined. The pro-inflammatory and bone resorptive properties of interleukin-l beta (IL-1 beta) strongly suggest a role for this cytokine in the pathogenesis of periodontal disease. In the study reported here, the frequency of IL-1 beta genotypes including allele 2 of the IL-1 beta(+3953) restriction fragment length bi-allelic polymorphism was significantly increased in patients with advanced adult periodontitis compared to those with early and moderate disease. Furthermore, allele 2 was associated with increased production of IL-1 beta by activated peripheral blood polymorphonuclear cells of patients with advanced disease, although this increase failed to reach statistical significance. Finally, the data obtained revealed significant linkage disequilibrium between allele 2 of the IL-1 beta(+3953) polymorphism and allele 2 of the bi-allelic LL-1 alpha(-889) polymorphism in both patients and orally healthy controls. These findings provide new insight into the possible role of IL-1 alpha and beta gene polymorphisms in the susceptibility to adult periodontitis.