Production of interferon-gamma in families with multiple occurrence of schizophrenia
Production of interferon-gamma in families with multiple occurrence of schizophrenia
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DOI：
10.1016/s0165-1781(96)03023-5
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发表时间：
1997-02-07
影响因子：
11.3
通讯作者：
Kirchner, H
中科院分区：
文献类型：
--
作者：
Arolt, V;Weitzsch, C;Kirchner, H
T细胞介导的免疫功能障碍，其由白细胞介素-2（IL-2）的产生不足和可溶性白细胞介素-2受体（sIL-2 R）的水平升高指示，在精神分裂症中一直得到证实。最近对干扰素-γ（IFN-γ）（一种也由T辅助细胞产生的细胞因子）的研究表明，在急性精神分裂症中，干扰素-γ的产生降低。目前尚不清楚这种缺陷是否仅限于急性精神分裂症病例，或者是否也存在于残留的精神分裂症和一级亲属中，因此可能与遗传易感性有关。我们调查了27个人（精神分裂症和一级亲属）的6个家庭多次发生精神分裂症和27个年龄和性别匹配的健康对照。与对照组和一级亲属相比，IFN-γ的产生仅在急性精神分裂症患者中降低。在当前知识的背景下，这一结果表明，IFN-γ的产生可以作为精神分裂症急性加重的标志物进行讨论，但它不太可能代表与该疾病相关的遗传性状的表型标志物。(C)1997 Elsevier Science爱尔兰有限公司
Dysfunction of T-cell mediated immunity, which is indicated by deficient production of interleukin-2 (IL-2) and elevated levels of the soluble interleukin-2 receptor (slL-2R), has been consistently demonstrated in schizophrenia. Recent studies on interferon-gamma (IFN-gamma), a cytokine which is also produced by T-helper cells, have indicated a lowered production in acute schizophrenia. It is not known whether this deficit is restricted to cases of acute schizophrenia or whether it is also present in residual schizophrenia and in first degree relatives, and therefore might be associated with genetic liability to the disease. We investigated 27 individuals (schizophrenics and first degree relatives) of 6 families with multiple occurrence of schizophrenia and 27 age- and sex-matched healthy controls. The production of IFN-gamma was lowered only in the acutely ill schizophrenic individuals, when compared to both controls and first degree relatives. In the context of current knowledge, this result indicates that the production of IFN-gamma can be discussed as a marker of acute exacerbation of schizophrenia, but it is not likely to represent a phenotypic marker of a genetic trait associated with the disease. (C) 1997 Elsevier Science Ireland Ltd.