Asymmetric aldol reaction using immobilized proline on mesoporous support
Asymmetric aldol reaction using immobilized proline on mesoporous support
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DOI：
10.1002/adsc.200505058
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发表时间：
2005-08-01
影响因子：
5.4
通讯作者：
Fernández-Mayoralas, A
中科院分区：
文献类型：
--
作者：
Calderón, F;Fernández, R;Fernández-Mayoralas, A
研究了在热和微波辅助下，以介孔载体固定化脯氨酸为催化剂，羟基丙酮与不同醛的羟醛缩合反应。结果表明，在亲水性和疏水性溶剂中，MCM-41负载的L-脯氨酸均能催化Aldol反应，并在某些情况下提供了与均相催化剂互补的立体选择性。该催化剂可重复使用，且立体选择性没有明显损失。
The aldol reaction of hydroxyacetone with different aldehydes using immobilized proline on a mesoporous support, assisted by heat and microwaves, has been explored. It was found that heterogenized L-proline on MCM-41 catalyzed aldol reactions in both hydrophilic and hydrophobic solvents, and provided stereoselectivities in some cases com-plementary to the homogeneous catalyst. The heterogeneous catalysts could be reused without significant lost of stereoselectivity.