Localization of the highly polymorphic microsatellite DXS456 on the genetic linkage map of the human X chromosome.
Localization of the highly polymorphic microsatellite DXS456 on the genetic linkage map of the human X chromosome.
复制标题
高度多态性微卫星 DXS456 在人类 X 染色体遗传连锁图上的定位。
DOI：
10.1016/0888-7543(91)90045-g
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发表时间：
1991
期刊：
影响因子：
4.4
通讯作者：
Litt,M
中科院分区：
文献类型：
--
作者：
Fain,PR;Luty,JA;Guo,Z;Nguyen,K;Barker,DF;Litt,M
CA 重复微卫星 DXS456 杂合度为 77%，已通过与其他 20 个遗传标记相关的多点连锁分析进行定位。 DXS456 映射到由侧翼标记 DXS178 和 DXS287 定义的 4.2-cM 间隔。标记的最大似然顺序 cen-(DXYS1X/DXYS13X/DXYS2X/DXYS12X)-DXS366-DXS178-DXS456-DXS287-DXS358-DXS267-qter 比最可能的替代顺序子集的赔率 > 1000:1 更受青睐。可以推断出 DXS456 的连锁至少有 6 个疾病基因，这些基因已知与 Xq21.31-Xq25 区域中的标记连锁，并且该标记将作为定位这些以及该区域中其他疾病和标记基因座的重要索引点。
The CA repeat microsatellite DXS456, with a heterozygosity of 77%, has been localized by multipoint linkage analysis in relation to 20 other genetic markers. DXS456 mapped to a 4.2-cM interval defined by the flanking markers DXS178 and DXS287. The maximum likelihood order of markers, cen-(DXYS1X/DXYS13X/DXYS2X/DXYS12X)-DXS366-DXS178-DXS456-DXS287-DXS358-DXS267-qter, is favored by odds > 1000:1 over the subset of most likely alternative orders. Linkage of DXS456 can be inferred for at least six disease genes that are known to be linked to markers in the region Xq21.31–Xq25 and the marker will serve as an important index point for orienting these and other disease and marker loci in the region.