Leptin, adiponectin, and heart rate variability among police officers.
Leptin, adiponectin, and heart rate variability among police officers.
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警察的瘦素，脂联素和心率变异性。
DOI：
10.1002/ajhb.22636
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发表时间：
2015-03
期刊：
影响因子：
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通讯作者：
Andrew ME
中科院分区：
文献类型：
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作者：
Charles LE;Burchfiel CM;Sarkisian K;Li S;Miller DB;Gu JK;Fekedulegn D;Violanti JM;Andrew ME
警察心血管疾病(CVD)的患病率很高。众所周知，心率变异性(HRV)降低会增加心血管疾病的风险。瘦素和脂联素可能与心血管疾病的健康有关。因此，我们的目标是研究这些变量与心率变异性之间的关系。来自水牛城心脏代谢职业警察压力研究的388名警官测量了瘦素和脂联素水平。根据欧洲心脏病学会和北美起搏电生理学学会发布的HRV测量和分析方法对HRV进行评估。用方差分析和协方差分析比较瘦素和脂联素的高频(HF)和低频(LF)心率变异性的平均值；用线性回归模型评估趋势。与HRV显著负相关的是瘦素，而不是脂联素。体重指数(BMI)和体脂百分比显著改变了瘦素和低频(但不是高频)HRV之间的关联。在体重指数为25 kg/m2的军官中，瘦素与心率变异性没有显著相关性。然而，在体重指数≥为25 kg/m2的军官中，在调整了年龄、性别和种族/民族后，瘦素与心率变异呈负相关；高频心率变异，P=0.019；低频心率变异，P<；0.0001。同样，在体脂百分比≥为25.5%的军官中，瘦素和低频心率变异性显示出显著的负相关(调整后的P=0.001)。瘦素水平与低频心率变异性呈负相关，特别是在肥胖增加的军官中。瘦素水平升高可能与心血管疾病相关的健康问题有关。
Police officers have a high prevalence of cardiovascular disease (CVD). Reduced heart rate variability (HRV) is known to increase CVD risk. Leptin and adiponectin may be related to CVD health. Therefore, our objective was to investigate the relationship between these variables and HRV. Leptin and adiponectin levels were measured in 388 officers from the Buffalo Cardio-Metabolic Occupational Police Stress study. HRV was assessed according to methods published by the Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology for measurement and analysis of HRV. Mean values of high-frequency (HF) and low-frequency (LF) HRV were compared across tertiles of leptin and adiponectin using analysis of variance and analysis of covariance; trends were assessed using linear regression models. Leptin, but not adiponectin, was significantly and inversely associated with HRV. Body mass index (BMI) and percent body fat significantly modified the association between leptin and LF (but not HF) HRV. Among officers with BMI < 25 kg/m2, leptin was not significantly associated with HRV. However, among officers with BMI ≥ 25 kg/m2, leptin was inversely associated with HRV, after adjustment for age, gender, and race/ethnicity; HF HRV, P = 0.019 and LF HRV, P < 0.0001. Similarly, among officers with percent body fat ≥ 25.5%, leptin and LF HRV showed significant, inverse associations (adjusted P = 0.001). Leptin levels were inversely associated with LF HRV, especially among officers with increased adiposity. Increased leptin levels may be associated with CVD-related health problems.