Blood pressure control in dialysis patients:: Importance of the lag phenomenon
Blood pressure control in dialysis patients:: Importance of the lag phenomenon
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DOI：
10.1016/s0272-6386(98)70147-7
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发表时间：
1998-11-01
影响因子：
13.2
通讯作者：
Scribner, BH
中科院分区：
文献类型：
--
作者：
Charra, B;Bergström, J;Scribner, BH
由于世界透析界未能理解和使用干重法控制血压（BP），导致难治性高血压的发病率不断上升，这仍然是心血管疾病发病率和死亡率的主要原因。这种失败的部分原因可能是细胞外体积（ECV）和血压之间的关系不是简单和线性的，而是复杂的，因为在时间平均ECV正常化和血压下降之间存在数周的滞后。这种失败的另一个原因可能是在高血压向正常血压过渡期间不愿意逐渐减少和停止所有降压药物。在本报告中，我们详细描述了滞后现象，记录了其他人群在治疗期间的存在，并描述了如何将这些知识应用于透析人群中无药物血压控制的干重法(C)， 1998年由国家肾脏基金会公司。
Failure by the world dialysis community to understand and use the dry-weight method of blood pressure (BP) control has resulted in an increasing incidence of treatment-resistant hypertension, which remains the principal cause of cardiovascular morbidity and mortality. This failure may in part be because the relationship between the extracellular volume (ECV) and BP is not simple and linear, but complex, because of a lag of several weeks between the normalization of the time-averaged ECV and the decrease in BP. Another cause for this failure may be the unwillingness to taper and stop all antihypertensive medications during the transition from hypertension to normotension, In this report, we describe in detail the lag phenomenon, document its presence during treatment in other populations, and describe how this knowledge is used in the application of the dry-weight method of drug-free BP control in the dialysis population, (C) 1998 by the National Kidney Foundation, Inc.