Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy.
Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy.
复制标题
针对癌症治疗的代谢可塑性和灵活性动力学。
DOI：
10.1158/2159-8290.cd-20-0844
复制
发表时间：
2020-12
期刊：
影响因子：
28.2
通讯作者：
Erez A
中科院分区：
文献类型：
--
作者：
Fendt SM;Frezza C;Erez A
Cancer cells continuously rewire their metabolism to fulfil their need for rapid growth and survival whilst subject to changes in environmental cues. Thus, a vital component of a cancer cell lies in its metabolic adaptability. The constant demand for metabolic alterations requires flexibility, i.e. the ability to utilize different metabolic substrates, as well as plasticity, i.e. the ability to process metabolic substrates in different ways. In this review, we discuss how dynamic changes in cancer metabolism affect tumour progression and the consequential implications for cancer therapy.
