Theranostic 2D Tantalum Carbide (MXene)
Theranostic 2D Tantalum Carbide (MXene)
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DOI：
10.1002/adma.201703284
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发表时间：
2018-01-25
影响因子：
29.4
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Lin, Han;Wang, Youwei;Shi, Jianlin
通过高温固相反应和烧结制备的大尺寸和刚性陶瓷块体从未被认为可能进入血管内并在血管内循环用于生物医学应用，特别是用于对抗癌症。在此，首次报道了MAX陶瓷生物材料在双模光声/计算机断层扫描成像方面表现出独特的功能，并且在剥离成原子厚度内的纳米片（MXene）后，对肿瘤的体内光热消融非常有效。作为一个范例，二维钽碳化纳米片（Ta 4C 3 MXenes）与纳米尺寸的横向尺寸成功地合成的基础上的两步液体剥离策略的MAX相Ta 4AlC 3的氢氟酸（HF）蚀刻和探针超声处理相结合。剥离的纳米片的结构，电子和表面特性揭示了各种表征结合第一性原理计算通过密度泛函理论。特别是，上级的光热转换性能（效率。的44.7%）和体外/体内光热消融肿瘤的生物相容性大豆磷脂修饰的Ta 4C 3纳米片系统地揭示和证明。基于MXenes的大家族成员，这项工作可能提供一个范例，即MXenes可以实现特定的生物医学应用（这里是治疗诊断），前提是它们的组成和纳米结构经过精心调整和优化，以满足生物医学的严格要求。
The large-dimensional and rigid ceramic bulks fabricated by high-temperature solid-phase reaction and sintering have never been considered for possibly entering and circulating within the blood vessels for biomedical applications, especially on combating cancer. Here, it is reported for the first time that MAX ceramic biomaterials exhibit unique functionalities for dual-mode photoacoustic/computed tomography imaging and are highly effective for in vivo photothermal ablation of tumors upon being exfoliated into ultrathin nanosheets within atomic thickness (MXene). As a paradigm, 2D ultrathin tantalum carbide nanosheets (Ta4C3 MXenes) with nanosized lateral sizes are successfully synthesized based on a two-step liquid exfoliation strategy of MAX phase Ta4AlC3 by combined hydrofluoric acid (HF) etching and probe sonication. The structural, electronic, and surface characteristics of the as-exfoliated nanosheets are revealed by various characterizations combined with first-principles calculations via density functional theory. Especially, the superior photothermal-conversion performance (efficiency. of 44.7%) and in vitro/in vivo photothermal ablation of tumor by biocompatible soybean phospholipid-modified Ta4C3 nanosheets are systematically revealed and demonstrated. Based on the large family members of MXenes, this work may offer a paradigm that MXenes can achieve the specific biomedical applications (here, theranostic) providing that their compositions and nanostructures are carefully tuned and optimized to meet the strict requirements of biomedicine.