Prevention of viral-chemical co-carcinogenesis in vitro by type-specific anti-viral antibody.
Prevention of viral-chemical co-carcinogenesis in vitro by type-specific anti-viral antibody.
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通过类型特异性抗病毒抗体在体外预防病毒化学协同致癌作用。
DOI：
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发表时间：
1976
影响因子：
11.1
通讯作者：
R. Huebner
中科院分区：
文献类型：
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作者：
P. Price;T. Bellew;M. P. King;A. Freeman;R. Gilden;R. Huebner
低传代 Fischer 大鼠胚胎培养物通常对 3-甲基胆蒽的转化具有很强的抵抗力，但当长期感染 Rauscher 鼠白血病病毒时高度敏感，当在甲基胆蒽治疗之前和治疗期间用针对白血病病毒的中和抗体进行处理时，可完全防止甲基胆蒽的转化。姐妹培养物未受到 B 向性辐射白血病病毒特异性中和抗体的保护。这清楚地证明了 Rauscher 鼠白血病病毒在大鼠细胞的 2-甲基胆蒽转化系统中的明确类型特异性作用。
Low passage Fischer rat embryo cultures, which are normally very resistant to transformation by 3-methylcholanthrene but are highly susceptible when chronically infected with the Rauscher murine leukemia virus, were completely protected from transformation by methylcholanthrene when treated with neutralizing antibody specific for the leukemia virus prior to and during treatment with methylcholanthrene. Sister cultures were not protected by neutralizing antibody specific for the B-tropic radiation leukemia virus. This demonstrates clearly a definite type specific role for Rauscher murine leukemia virus in the 2-methylcholanthrene transformation system in rat cells.