Degree of hippocampal atrophy is not related to a history of febrile seizures in patients with proved hippocampal sclerosis
Degree of hippocampal atrophy is not related to a history of febrile seizures in patients with proved hippocampal sclerosis
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DOI：
10.1136/jnnp.69.6.733
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发表时间：
2000-12-01
影响因子：
11
通讯作者：
Cook, MJ
中科院分区：
文献类型：
--
作者：
Bower, SPC;Kilpatrick, CJ;Cook, MJ
目的：检测颞叶癫痫患者海马萎缩的程度，并证实海马硬化，以确定热性惊厥患者是否有更严重的海马萎缩。为了确定癫痫发作的年龄、颞叶癫痫的持续时间或癫痫发作的频率与海马萎缩的严重程度之间是否存在关系，方法：对77例连续手术治疗的颞叶癫痫患者进行海马体积测量（37例FS+，40例FS-），并与98例正常对照组比较。两组之间在习惯性癫痫发作的年龄、癫痫持续时间或手术时的年龄方面没有差异。在有和没有热性惊厥的患者中，海马体积和首次非热性惊厥发作的年龄、颞叶癫痫的持续时间或复杂的部分性和继发性全身性癫痫发作频率之间没有临床显著相关性。MRI确定的海马萎缩程度与此类癫痫发作史无关。结果不支持热性惊厥导致更严重的海马硬化的观点，并且与海马硬化是预先存在的异常的假设一致。
Objectives-To examine the degree of hippocampal atrophy in patients with temporal lobe epilepsy and proved hippocampal sclerosis to determine whether or not patients with febrile seizures have more severe hippocampal atrophy. To determine whether or not there is a relation between age of seizure onset, duration of temporal lobe epilepsy, or seizure frequency, and severity of hippocampal atrophy.Methods-Hippocampal volumes were measured from volumetrically acquired MR images in 77 consecutive surgical patients with temporal lobe epilepsy (37 febrile seizures (FS)+, 40 FS-) with proved hippocampal sclerosis, and compared with 98 controls.Results-Ipsilateral and contralateral hippocampal volumes were not significantly different between the FS+ and FS-groups. There was no difference in the age of onset of habitual seizures, duration of epilepsy, or age at the time of surgery between these groups. No clinically significant correlations were found between hippocampal volumes and age of onset of first non-febrile seizure, duration of temporal lobe epilepsy, or complex partial and secondarily generalised seizure frequency, in patients with and without febrile seizures.Conclusions-Although febrile seizures was associated with hippocampal sclerosis in 48% of patients in this surgical series, the degree of MRI determined hippocampal atrophy was not related to a history of such seizures. The results do not support the view that febrile seizures cause more severe hippocampal sclerosis and are consistent with the hypothesis that hippocampal sclerosis is a pre-existing abnormality.