Antimicrobial constituents of Scrophularia deserti
Antimicrobial constituents of Scrophularia deserti
复制标题
DOI：
10.1016/j.phytochem.2006.05.011
复制
发表时间：
2006-07-01
期刊：
影响因子：
3.8
通讯作者：
Gibbons, Simon
中科院分区：
文献类型：
--
作者：
Stavri, Michael;Mathew, K. T.;Gibbons, Simon
通过对玄参化学成分和抗菌活性的研究，分离得到8个化合物，包括代谢产物3(Zeta)-羟基-十八烷-4(E)，6(Z)-二烯酸(1)。分离得到5个化合物，分别为：鬼臼皂苷(2)、黑曲霉糖苷B(3)、6-O-α-L-鼠李糖基葡萄糖醇(4)、花蕾皂苷A(8)(5)、螺旋藻糖苷A(6)、侧柏糖苷(7)和3R-1-辛烷-3-基-3-O-β-D-吡喃葡萄糖苷(8)。化合物1-3对多种药物和耐甲氧西林金黄色葡萄球菌(MRSA)以及一组快速生长的分枝杆菌表现出中等的抗菌活性，最低抑菌浓度(MIC)值在32至128微克/毫升之间。(C)2006爱思唯尔有限公司。保留所有权利。
A study of the chemistry and antibacterial activity of Scrophularia deserti led to the isolation of eight compounds, including the metabolite 3(zeta)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (1). The known compounds ajugoside (2), scropolioside B (3), 6-O-alpha-L-rhamnopyranosylcatalpol (4), buddlejoside A(8) (5), scrospioside A (6), laterioside (7) and 3R-1-octan-3-yl-3-O-beta-D-glucopyranoside (8) were also isolated. Compounds 1-3 exhibited moderate antibacterial activity against strains of multidrug and methicillin-resistant Staphylococcus aureus (MRSA) and a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values ranging from 32 to 128 mu g/ml. (c) 2006 Elsevier Ltd. All rights reserved.