Graphene-based hybrid materials as promising scaffolds for peripheral nerve regeneration
Graphene-based hybrid materials as promising scaffolds for peripheral nerve regeneration
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DOI：
10.1016/j.neuint.2021.105005
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发表时间：
2021-05-31
影响因子：
4.2
通讯作者：
Diaz, David Diaz
中科院分区：
文献类型：
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作者：
Grijalvo, Santiago;Diaz, David Diaz
周围神经损伤（peripheral nerve injury，PNI）是由周围神经损伤引起的严重的临床健康问题，可导致神经功能缺损和永久性残疾。有几个因素可能导致PNI，如局部损伤（车祸，创伤，电击伤）和全身性疾病（自身免疫性或糖尿病）的爆发。虽然各种诊断程序，包括X射线，磁共振成像（MRI），以及其他类型的检查，如肌电图或神经传导研究已经有效地开发，在PNI患者的完全恢复在许多情况下是不足或不完全的。这就是为什么应该探索额外的治疗策略以利于完全康复，从而获得适当的神经损伤再生的原因。生物材料作为支架的使用在再生医学和组织工程应用中开辟了一种有趣的方法，因为它们能够引导新组织的生长、细胞的粘附和增殖，包括生物活性信号的表达。这篇综述讨论了制备和治疗策略，描述了在PNI及其促进神经组织再生的能力的背景下使用石墨烯基材料的体外和体内实验。
Peripheral nerve injury (PNI) is a serious clinical health problem caused by the damage of peripheral nerves which results in neurological deficits and permanent disability. There are several factors that may cause PNI such as localized damage (car accident, trauma, electrical injury) and outbreak of the systemic diseases (autoimmune or diabetes). While various diagnostic procedures including X-ray, magnetic resonance imaging (MRI), as well as other type of examinations such as electromyography or nerve conduction studies have been efficiently developed, a full recovery in patients with PNI is in many cases deficient or incomplete. This is the reason why additional therapeutic strategies should be explored to favor a complete rehabilitation in order to get appropriate nerve injury regeneration. The use of biomaterials acting as scaffolds opens an interesting approach in regenerative medicine and tissue engineering applications due to their ability to guide the growth of new tissues, adhesion and proliferation of cells including the expression of bioactive signals. This review discusses the preparation and therapeutic strategies describing in vitro and in vivo experiments using graphene-based materials in the context of PNI and their ability to promote nerve tissue regeneration.