Issues in quantifying atrophic macular disease using retinal autofluorescence
Issues in quantifying atrophic macular disease using retinal autofluorescence
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DOI：
10.1097/00006982-200607000-00013
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发表时间：
2006-07-01
影响因子：
3.3
通讯作者：
Applegate, Carol A.
中科院分区：
文献类型：
--
作者：
Sunness, Janet S.;Ziegler, Matthias D.;Applegate, Carol A.
目的：为了证明的潜力和限制的自体荧光成像在识别和划定区域atrophysics.Methods：眼底照片和红外扫描激光检眼镜（SLO）成像，SLO黄斑视野检查，SLO自体荧光成像结果进行了比较，为两例地图状萎缩（GA）的年龄相关性黄斑变性，一名患者的视网膜色素改变，和两名患者与Stargardt病。在这种情况下，一系列的主要结果措施是存在减少autofluorescence.Results：玻璃疣可能会成为检测不到的一些患者在自体荧光成像，允许简单的识别领域的GA与领域的减少自体荧光。在其他患者中，玻璃疣本身具有减少的自体荧光，尽管在覆盖它们的视网膜中具有完整的视网膜功能。一些患者可能有持续多年的自体荧光减少的区域，而没有萎缩发展的证据。在Stargardt病中，减少的自体荧光可以容易地检测和描绘暗点区域。斑驳的自体荧光区可能有重叠的功能，但功能可能不足以支持在该area.Conclusions固定位点：使用减少自体荧光描绘萎缩的区域可能是有帮助的萎缩性黄斑病变。对于GA，与眼底照片或黄斑视野检查结果的相关性可能是必要的，以区分玻璃疣和萎缩。对于Stargardt病，自发荧光减少区域的性质可能有助于解释这些区域的视觉功能。
Purpose: To demonstrate the potential and limits of autofluorescence imaging in identifying and delineating areas of atrophy.Methods: Fundus photographs and infrared scanning laser ophthalmoscope (SLO) imaging, SLO macular perimetry, and SLO autofluorescence imaging results were compared for two patients with geographic atrophy (GA) from age-related macular degeneration, one patient with pigmentary alteration of the retina, and two patients with Stargardt disease. The main outcome measure in this case series was the presence of reduced autofluorescence.Results: Drusen may become undetectable during autofluorescence imaging for some patients, allowing simple identification of areas of GA with areas of reduced autofluorescence. In other patients, drusen themselves have decreased autofluorescence, despite having intact retinal function in the retina overlying them. Some patients may have areas of reduced autofluorescence that persist for many years, without evidence of the development of atrophy. In Stargardt disease, decreased autofluorescence can easily detect and delineate areas of scotoma. Areas with mottled autofluorescence may have overlying function, but the function may not be adequate to support a fixation locus in that area.Conclusions: Using decreased autofluorescence to delineate areas of atrophy may be helpful in atrophic macular disorders. For GA, correlation with fundus photographs or macular perimetry findings may be necessary to differentiate between drusen and atrophy. For Stargardt disease, the nature of areas of decreased autofluorescence may help explain visual function of those areas.