ANTIBODY-RESPONSES TO VARICELLA-ZOSTER VIRUS AND THE ROLE OF ANTIBODY IN HOST DEFENSE
ANTIBODY-RESPONSES TO VARICELLA-ZOSTER VIRUS AND THE ROLE OF ANTIBODY IN HOST DEFENSE
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DOI：
10.1097/00000441-198107000-00002
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发表时间：
1981-01-01
影响因子：
3.1
通讯作者：
STEINBERG, SP
中科院分区：
文献类型：
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作者：
GERSHON, AA;STEINBERG, SP
对1~85岁人群进行水痘-带状疱疹(VZ)病毒抗体滴度测定。在整个50岁期间，血清阳性个体的百分比继续上升。随着年龄的增长，几何平均滴度没有下降，老年人的VZ抗体滴度可能有所增加。随着年龄的增长，VZ抗体的下降似乎不太可能解释老年人带状疱疹发病率的增加。同样，免疫功能低下的患者比正常人更容易患带状疱疹，但VZ抗体效价并不比正常人低。免疫受损的播散型带状疱疹患者的抗体滴度略高于免疫受损的局限性带状疱疹患者。体液免疫对带状疱疹的发生或病程影响很小，甚至没有影响。
Antibody titers to varicella-zoster (VZ) virus in persons aged 1-85 yr were measured. Through age 50, the percent of seropositive individuals continued to rise. There was no fall in geometric mean titer with aging and there may have been an increase in VZ antibody titer in older persons. A fall in VZ antibody with increasing age does not seem likely to account for the increased incidence of zoster in the elderly. Similarly, immunocompromised patients who are more likely to develope zoster than normals did not have lower VZ antibody titers than normal persons. Immunocompromised persons with disseminated zoster had antibody titers that were somewhat higher than those of immunocompromised persons with localized zoster. Humoral immunity may have little or no influence on either the development or the course of herpes zoster.