Kigamicins, novel antitumor antibiotics - II. Structure determination
Kigamicins, novel antitumor antibiotics - II. Structure determination
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DOI：
10.7164/antibiotics.56.1012
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发表时间：
2003-12-01
影响因子：
3.3
通讯作者：
Naganawa, H
中科院分区：
文献类型：
--
作者：
Kunimoto, S;Someno, T;Naganawa, H
Kigamicin A(1)、B(2)、C(3)、D(4)和E(5)是新型抗肿瘤抗生素。通过包括各种核磁共振测量在内的光谱分析确定了它们的结构。Kigamicins具有独特的稠合八环系统的苷元，包含七个六元环和一个恶唑烷。苷元连接一个由一到四个脱氧糖组成的糖链。这些糖被发现是阿米托糖和棕榈糖。
Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of six-membered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.