Quantification of tissue plasma volume in the rat by contrast-enhanced magnetic resonance imaging.
Quantification of tissue plasma volume in the rat by contrast-enhanced magnetic resonance imaging.
复制标题
通过对比增强磁共振成像定量大鼠组织血浆体积。
DOI：
10.1002/mrm.1910300112
复制
发表时间：
1993
影响因子：
3.3
通讯作者：
Brasch,RC
中科院分区：
文献类型：
--
作者：
Kuwatsuru,R;Shames,DM;Mühler,A;Mintorovitch,J;Vexler,V;Mann,JS;Cohn,F;Price,D;Huberty,J;Brasch,RC
用大分子造影剂（MMCM）-白蛋白-Gd-DTPA增强的磁共振成像，估计10只正常大鼠心肌、肺、肝和骨骼肌的血浆体积。通过常规放射性同位素技术（111 In-转铁蛋白）在体外估计平行组6只大鼠相同组织的血浆体积。通过MR技术估计的心肌、肺、肝和骨骼肌的血浆体积（μl plas. ia cc-1组织）分别为101、109、163和11.0，而通过转铁蛋白放射性同位素技术测量的血浆体积（mg血浆g-1组织）分别为78.6、215、143和11 - 2。假设充气肺与血液的密度比为0.45，其他组织与血液的密度比为1.0，则两种方法之间的相关性极好（R2= 0.99），表明用MMCM增强的MR成像允许可靠地在大鼠体内估计组织血浆体积。
Magnetic resonance imaging enhanced with a macromolecular contrast medium (MMCM), albumin‐Gd‐DTPA, was used to estimate the plasma volumein vivoin the myocardium, lung, liver, and skeletal muscle of 10 normal rats. The plasma volumes of the same tissues in a parallel group of six rats were estimatedin vitroby a conventional radioisotopic technique (111In‐transferrin). Plasma volumes of myocardium, lung, liver, and skeletal muscle estimated by the MR technique (μl plas. ia cc‐1of tissue) were 101,109,163, and 11.0, respectively, while plasma volumes measured by the In‐transferrin radioisotope technique (mg plasma g‐1of tissue) were 78.6, 215,143, and 11‐2, respectively. Assuming a ratio of densities of aerated lung to blood of 0.45 and of other tissues to blood of 1.0, correlation between the methods was excellent (R2= 0.99) indicating that MR imaging enhanced with MMCM permits reliablein vivoestimation of tissue plasma volume in the rat.