Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004
Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004
复制标题
DOI：
10.1136/jnnp.2007.117788
复制
发表时间：
2008-01-01
影响因子：
11
通讯作者：
Hardiman, O.
中科院分区：
文献类型：
--
作者：
O'Toole, O.;Traynor, B. J.;Hardiman, O.
背景资料：我们进行了一项前瞻性的、基于人群的研究，以检查1995年至2004年爱尔兰肌萎缩侧索硬化症（ALS）的发病率和患病率的趋势。爱尔兰ALS登记用于识别1995年1月1日至1997年12月31日的3年期间和2002年1月1日至31日的3年期间诊断为ALS的爱尔兰居民。结果：在研究期间，465名爱尔兰居民被诊断为ALS。在此期间，爱尔兰ALS的年发病率保持稳定（2.0例/100 000人-年; 95% CI 1.9，2.2）。爱尔兰ALS患者的中位生存期为16.4个月，在研究期间没有变化。爱尔兰ALS发病和流行队列的人口统计学和临床特征明显不同。
Background: We conducted a prospective, population based study to examine trends in incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Ireland from 1995 to 2004.Methods: The Irish ALS Register was used to identify Irish residents diagnosed with ALS between the 3 year period from 1 January 1995 to 31 December 1997 and the 3 year period from 1 January 2002 to 31 December 2004.Results: 465 Irish residents were diagnosed with ALS during the study periods. The annual incidence rate of ALS in Ireland remained stable over this time (2.0 cases per 100 000 person-years; 95% CI 1.9, 2.2). Median survival of Irish ALS patients was 16.4 months and did not change during the study period. Demographics and clinical features of the incident and prevalent Irish ALS cohorts were markedly different.