Regiospecific Synthesis of Benzoxepines through Pd-Catalyzed Carbene Migratory Insertion and C-C Bond Cleavage.
Regiospecific Synthesis of Benzoxepines through Pd-Catalyzed Carbene Migratory Insertion and C-C Bond Cleavage.
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DOI：
10.1021/acs.joc.5b02413
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Yang Xie;Ping Zhang;Lei Zhou
中科院分区：
文献类型：
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作者：
Yang Xie;Ping Zhang;Lei Zhou
提出了一种通过迁移插入Pd卡宾并裂解C-C键合成苯并西平的新方法。通过在5位上引入芳基的区域选择性扩环，构建了多种苯并西平类化合物。
A new method for the synthesis of benzoxepines via migratory insertion into a Pd carbene followed by C-C bond cleavage was developed. Various benzoxepines were constructed by the regioselective ring expansion concomitant with the introduction of an aryl group at their 5-position.