Neural cognitive signals during spontaneous movements in the macaque.
Neural cognitive signals during spontaneous movements in the macaque.
复制标题
猕猴自发运动期间的神经认知信号。
DOI：
10.1038/s41593-022-01220-4
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发表时间：
2023
影响因子：
25
通讯作者：
Petrides,Michael
中科院分区：
文献类型：
--
作者：
Tremblay,Sébastien;Testard,Camille;DiTullio,RonW;Inchauspé,Jeanne;Petrides,Michael
灵长类动物认知处理的单神经元基础主要是在实验室环境中研究的，那里的运动受到严重限制。因此，目前尚不清楚自然运动如何影响大脑中认知的神经特征。此外，对老鼠的研究表明，当测量身体运动时，大脑皮层的大部分神经动力学都是由身体运动引起的。为了研究这些问题，我们记录了猴子在执行认知任务时前额叶皮层的单个神经元集合，并使用视频跟踪来描述眼睛、头部和身体的运动。尽管有相当大的试验到试验的运动可变性，单神经元调谐可以精确测量和决策信号准确解码在单次试验的基础上。通过头部约束和任务操作产生或取消自发运动对神经反应没有可测量的影响。然而，编码模型显示，未经指示的动作解释了与任务变量一样多的神经变异，大多数动作与任务事件一致。这些结果表明，皮层中的认知信号对自然运动具有很强的响应能力，但在认知神经生理学实验中，未测量到的运动也可能是潜在的干扰。
The single-neuron basis of cognitive processing in primates has mostly been studied in laboratory settings where movements are severely restricted. It is unclear, therefore, how natural movements might affect neural signatures of cognition in the brain. Moreover, studies in mice indicate that body movements, when measured, account for most of the neural dynamics in the cortex. To examine these issues, we recorded from single-neuron ensembles in the prefrontal cortex in moving monkeys performing a cognitive task and characterized eye, head and body movements using video tracking. Despite considerable trial-to-trial movement variability, single-neuron tuning could be precisely measured and decision signals accurately decoded on a single-trial basis. Creating or abolishing spontaneous movements through head restraint and task manipulations had no measurable impact on neural responses. However, encoding models showed that uninstructed movements explained as much neural variance as task variables, with most movements aligned to task events. These results demonstrate that cognitive signals in the cortex are robust to natural movements, but also that unmeasured movements are potential confounds in cognitive neurophysiology experiments.