CRH: The link between hormonal-, metabolic- and behavioral responses to stress
CRH: The link between hormonal-, metabolic- and behavioral responses to stress
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DOI：
10.1016/j.jchemneu.2013.05.003
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发表时间：
2013-12-01
影响因子：
2.8
通讯作者：
Kovacs, Krisztina J.
中科院分区：
文献类型：
--
作者：
Kovacs, Krisztina J.
两个主要的和相互关联的大脑系统在应激反应期间被招募。一个是下丘脑室旁核（PVH），第二个是扩展杏仁核。PVH控制神经内分泌应激反应，而CeA调节大多数自主和行为应激反应。这些反应的共同神经激素介质是促肾上腺皮质激素释放激素，CRH，它在两个中心都有表达。CRH属于一个更大的神经肽家族，还包括尿皮质素1、2和3，它们对两种类型的CRHR受体都具有不同的亲和力，并参与应激和HPA轴活性的调节。CRH系统的一个功能相关方面是糖皮质激素对它们的差异调节。皮质酮抑制PVH中CRH的转录，而应激诱导的糖皮质激素刺激扩展杏仁核中CRH的表达。本文综述了CRH基因调控及其参与神经内分泌、自主神经和行为应激反应的研究进展。(C)2013爱思唯尔有限公司版权所有。
Two major and mutually interconnected brain systems are recruited during stress reaction. One is the hypothalamic paraventricular nucleus (PVH) and the second is the extended amygdala. PVH governs the neuroendocrine stress response while CeA regulates most of the autonomic and behavioral stress reactions. The common neurohormonal mediator of these responses is the corticotropin-releasing hormone, CRH, which is expressed in both centers. CRH belongs to a larger family of neuropeptides that also includes urocortins 1, 2, and 3 all have different affinity toward the two types of CRHR receptors and have been implicated in regulation of stress and HPA axis activity. One functionally relevant aspect of CRH systems is their differential regulation by glucocorticoids. While corticosterone inhibits CRH transcription in the PVH, stress-induced glucocorticoids stimulate CRH expression in the extended amygdala. This review summarizes past and recent findings related to CRH gene regulation and its involvement in the neuroendocrine, autonomic and behavioral stress reaction. (C) 2013 Elsevier B.V. All rights reserved.