Congenital helpless rats as a genetic model for cortex metabolism in depression.
Congenital helpless rats as a genetic model for cortex metabolism in depression.
复制标题
先天性无助大鼠作为抑郁症皮质代谢的遗传模型。
DOI：
10.1097/00001756-200011270-00040
复制
发表时间：
2000
期刊：
影响因子：
1.7
通讯作者：
Gonzalez-Lima,F
中科院分区：
文献类型：
--
作者：
Shumake,J;Poremba,A;Edwards,E;Gonzalez-Lima,F
在被认为与人类神经成像研究中显示异常的大脑皮质区域类似的大鼠大脑皮质区域，研究了先天性无助作为人类抑郁的遗传大鼠模型的有效性。用定量细胞色素氧化酶组织化学方法分析大脑皮层代谢。先天性无助大鼠的额叶和扣带区的变化与那些在人类抑郁症中表现出新陈代谢差异的变化相似。前额背侧、内侧眼眶和前扣带回的代谢显著降低，而膝下扣带回的代谢显著增加。这些变化的方向与人类研究中看到的方向相同。这些发现支持了先天无助作为人类抑郁模型的有效性。
The validity of congenital helplessness as a genetic rat model for human depression was investigated in cortical regions of the rat brain thought to be analogous to those showing abnormalities in human neuroimaging studies. Cortex metabolism was analyzed using quantitative cytochrome oxidase histochemistry. Congenital helpless rats showed changes in frontal and cingulate regions comparable to those that have demonstrated metabolic differences in human depression. Significant metabolic decreases were found in dorsal frontal, medial orbital, and anterior cingulate, whereas a significant increase was found in infraradiata (subgenual) cingulate. The direction of these changes were the same as those seen in human studies. These findings support the validity of congenital helplessness as a model for human depression.