Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis
Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis
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DOI：
10.1111/j.1468-3083.2011.04077.x
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发表时间：
2012-03-01
影响因子：
9.2
通讯作者：
Kadono, T.
中科院分区：
文献类型：
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作者：
Masui, Y.;Asano, Y.;Kadono, T.
目的探讨脂联素在系统性硬化症(SSC)发病过程中的临床意义。方法采用双抗体夹心酶联免疫吸附试验(EL ISA)检测32例弥漫性皮肤SSC(DcSSc)、28例局限性皮肤SSC(LcSSc)和27例健康体检者(对照组)血清脂联素水平。结果dcSSc患者血清脂联素水平(4.93+/-6.48mU/mL)显著低于lcSSc患者(9.69+/-7.61mU/L，P<0.01)和健康对照组(9.36+/-5.57mU/L，P<；0.01)。DcSSc患者病程为5年(13.29±8.36mU/m L，P<0.01)，lcSSc患者病程为5年(10.9±7.34mU/L，P<0.01)，健康对照组(9.36±/-5.57mU/L，P<；0.01)。对口服泼尼松治疗的5例早期DcSSc患者的纵向研究表明，血清脂联素水平与DcSSc患者进展性皮肤硬化的活动性呈负相关。结论血清脂联素水平可作为评价DcSSc进行性皮肤硬化活动性的有用指标。接收日期：2011年1月23日；接受日期：2011年3月22日
Backgrounds Adiponectin has been demonstrated to be one of anti-inflammatory and anti-fibrotic factors, suggesting the potential of this cytokine to be involved in the developmental process of systemic sclerosis (SSc).Objective The aim of this study was to investigate the clinical significance of serum adiponectin levels in patients with SSc.Methods Serum adiponectin levels were determined using enzyme-linked immunosorbent assay (ELISA) in 32 patients with diffuse cutaneous SSc (dcSSc), 28 with limited cutaneous SSc (lcSSc) and 27 healthy controls. No significant difference between these groups existed in terms of gender, age and body mass index.Results Serum adiponectin levels in dcSSc patients (4.93 +/- 6.48 mu g/mL) were significantly lower than those in lcSSc patients (9.69 +/- 7.61 mu g/mL, P < 0.01) and healthy controls (9.36 +/- 5.57 mu g/mL, P < 0.01). dcSSc patients with disease duration of 5 years (13.29 +/- 8.36 mu g/mL, P < 0.01), lcSSc patients with disease duration of 5 years (10.9 +/- 7.34 mu g/mL, P < 0.01) and healthy controls (9.36 +/- 5.57 mu g/mL, P < 0.01). Longitudinal studies in five patients with early dcSSc treated with oral prednisone demonstrated that serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in dcSSc patients.Conclusion Serum levels of adiponectin may serve as a useful marker to evaluate the activity of progressive skin sclerosis in dcSSc. Received: 23 January 2011; Accepted: 22 March 2011