CHEMICAL TRANSMISSION BETWEEN RAT SYMPATHETIC NEURONS AND CARDIAC MYOCYTES DEVELOPING IN MICROCULTURES - EVIDENCE FOR CHOLINERGIC, ADRENERGIC, AND DUAL-FUNCTION NEURONS
CHEMICAL TRANSMISSION BETWEEN RAT SYMPATHETIC NEURONS AND CARDIAC MYOCYTES DEVELOPING IN MICROCULTURES - EVIDENCE FOR CHOLINERGIC, ADRENERGIC, AND DUAL-FUNCTION NEURONS
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DOI：
10.1073/pnas.73.11.4225
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发表时间：
1976-01-01
影响因子：
11.1
通讯作者：
POTTER, DD
中科院分区：
文献类型：
--
作者：
FURSHPAN, EJ;MACLEISH, PR;POTTER, DD
在300-500 .mu的微培养上进行电生理研究。在这个实验中，新生大鼠孤立的交感主神经元生长在先前分离的大鼠心脏细胞上。一些神经元抑制，一些兴奋，另一些先抑制后兴奋心肌细胞。药物应用证明第一组分泌乙酰胆碱，第二组分泌儿茶酚胺，第三组分泌乙酰胆碱和儿茶酚胺。抑制肌细胞的孤立神经元通常在烟碱突触（autapses）上兴奋。
Electrophysiological studies were made on microcultures (300-500 .mu.m in diameter) in which solitary sympathetic principal neurons from newborn rats grew on previously dissociated rat heart cells. Some neurons inhibited, some excited and others first inhibited and then excited the cardiac myocytes. Application of drugs provided evidence for secretion of acetylcholine by the 1st group, catecholamines by the second, and both acetylcholine and catecholamines by the third. Solitary neurons which inhibited the myocytes usually excited themselves at nicotinic synapses (autapses).