Effects of bone-specific physical activity, gender and maturity on tibial cross-sectional bone material distribution: a cross-sectional pQCT comparison of children and young adults aged 5-29 years
Effects of bone-specific physical activity, gender and maturity on tibial cross-sectional bone material distribution: a cross-sectional pQCT comparison of children and young adults aged 5-29 years
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DOI：
10.1016/j.bone.2014.11.015
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发表时间：
2015-03-01
期刊：
影响因子：
4.1
通讯作者：
Beck, Belinda R.
中科院分区：
文献类型：
--
作者：
Rantalainen, Timo;Weeks, Benjamin K.;Beck, Belinda R.
生长是调整骨积累的好时机。虽然已知骨适应依赖于局部载荷和随之而来的骨变形（应变），但关于性别和骨特异性身体活动对生长过程中特定位置的横截面骨几何形状的影响知之甚少。为了提供更多的见解，我们检查了胫骨横截面周围不同位置的骨骼特征，以及不同身体活动、性别和青春期状态的个体之间的骨骼特征。分析了304名5-29岁个体（172名男性，132名女性）的数据。周围定量计算机断层扫描（pQCT）应用于胫骨长度的4%，14%，38%和66%。成熟度通过估算峰高速度（APHV）来确定。用骨特异性体力活动问卷（BPAQ）对负荷史进行量化。比较，调整身高，体重和年龄之间的性别，成熟度和BPAQ不育组。在APHV之前，两性之间或BPAQ分位数之间几乎没有差异，而在APHV之后，BPAQ分位数之间存在明显的两性二态性和差异。在APHV之前，BPAQ的横断面位置特异性差异不明显，而在APHV之后，观察到明确的位置特异性。总之，体力活动对骨骼的益处是胫骨特定部位的。目前的结果表明，与青春期前相比，青春期前后可能是增强横截面骨几何形状的更有利的机会窗口。青春期前期负荷的增加可以增强两性骨骼。(C) 2014爱思唯尔公司版权所有。
Growth is the opportune time to modify bone accrual. While bone adaptation is known to be dependent on local loading and consequent deformations (strain) of bone, little is known about the effects of sex, and bone-specific physical activity on location-specific cross-sectional bone geometry during growth. To provide more insight we examined bone traits at different locations around tibial cross sections, and along the tibia between individuals who vary in terms of physical activity exposure, sex, and pubertal status. Data from 304 individuals aged 5-29 years (172 males, 132 females) were examined. Peripheral quantitative computed tomography (pQCT) was applied at 4%, 14%, 38%, and 66% of tibial length. Maturity was established by estimating age at peak height velocity (APHV). Loading history was quantified with the bone-specific physical activity questionnaire (BPAQ). Comparisons, adjusted for height, weight and age were made between sex, maturity, and BPAQ tertile groups. Few to no differences were observed between sexes or BPAQ tertiles prior to APHV, whereas marked sexual dimorphism and differences between BPAQ tertiles were observed after APHV. Cross-sectional location-specific differences between BPAQ tertiles were not evident prior to APHV, whereas clear location-specificity was observed after APHV. In conclusion, the skeletal benefits of physical activity are location-specific in the tibia. The present results indicate that the peri- or post-pubertal period is likely a more favourable window of opportunity for enhancing cross-sectional bone geometry than pre-puberty. Increased loading during the pen-pubertal period may enhance the bone of both sexes. (C) 2014 Elsevier Inc. All rights reserved.