Evaluating anti-Orthopoxvirus antibodies in individuals from Brazilian rural areas prior to the bovine vaccinia era.
Evaluating anti-Orthopoxvirus antibodies in individuals from Brazilian rural areas prior to the bovine vaccinia era.
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DOI：
10.1590/0074-02760150215
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发表时间：
2015-09
影响因子：
2.8
通讯作者：
Trindade Gde S
中科院分区：
文献类型：
--
作者：
Figueiredo Pde O;Silva-Fernandes AT;Mota BE;Costa GB;Borges IA;Ferreira PC;Abrahão JS;Braga EM;Kroon EG;Trindade Gde S
痘苗病毒在巴西自然传播，是牛痘苗 (BV) 人畜共患疾病的病原体。我们回顾性评估了来自亚马逊和东南地区的两个种群。在样本采集之前，这些地区尚未报告细菌性阴道病疫情。在 13 名个体 (n = 132) 中发现中和抗体，滴度范围为 100 ≥ 6,400 中和单位/mL。单变量分析确定年龄和疫苗接种是东南地区个体具有统计学意义的危险因素。接种疫苗的个体中缺乏可检测到的抗体，引发了人们对接种疫苗数年后天花疫苗的保护作用产生了疑问，并加强了在没有先前爆发证据的巴西人群中监测正痘病毒的必要性。
Vaccinia virus naturally circulates in Brazil and is the causative agent of a zoonotic disease known as bovine vaccinia (BV). We retrospectively evaluated two populations from the Amazon and Southeast Regions. BV outbreaks had not been reported in these regions before sample collection. Neutralising antibodies were found in 13 individuals (n = 132) with titres ranging from 100 ≥ 6,400 neutralising units/mL. Univariate analysis identified age and vaccination as statistically significant risk factors in individuals from the Southeast Region. The absence of detectable antibodies in vaccinated individuals raises questions about the protection of smallpox vaccine years after vaccination and reinforces the need for surveillance of Orthopoxvirus in Brazilian populations without evidence of previous outbreaks.