LOCATION OF POLIO GENOME PROTEIN IN VIRAL RNAS AND ITS IMPLICATION FOR RNA-SYNTHESIS
LOCATION OF POLIO GENOME PROTEIN IN VIRAL RNAS AND ITS IMPLICATION FOR RNA-SYNTHESIS
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DOI：
10.1038/268208a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
WIMMER, E
中科院分区：
文献类型：
--
作者：
NOMOTO, A;DETJEN, B;WIMMER, E
有证据表明，小蛋白（VPg）共价连接到脊髓灰质炎基因组的5“-末端寡核苷酸VPg-pU-U-A-A-A-A-C-A-Gp，脊髓灰质炎复制中间体的新生链和负链的poly（U）。脊髓灰质炎RNA复制的模型提出牵连VPg在RNA合成的启动，可能作为引物。
Evidence is presented that a small protein (VPg) is covalently attached to the 5''-terminal oligonucleotide VPg-pU-U-A-A-A-A-C-A-Gp of the polio genome, to nascent strands of the polio replicative intermediate and to poly(U) of minus strands. A model of polio RNA replication is proposed implicating VPg in initiation of RNA synthesis, possibly as primer.