Involvement of central amygdalar and bed nucleus of the stria terminalis corticotropin-releasing factor in behavioral responses to social defeat
Involvement of central amygdalar and bed nucleus of the stria terminalis corticotropin-releasing factor in behavioral responses to social defeat
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DOI：
10.1037/0735-7044.118.5.1052
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发表时间：
2004-10-01
影响因子：
1.9
通讯作者：
Huhman, KL
中科院分区：
文献类型：
--
作者：
Jasnow, AM;Davis, M;Huhman, KL
作者研究了杏仁中央核（CeA）和终纹床核（BNST）内的促肾上腺皮质激素释放因子（CRF）是否是介导条件性失败的神经回路的关键组成部分。在这个模型中，仓鼠经历了社会失败，随后显示只有服从防御的竞争行为，而不是领土侵略。将CRF受体拮抗剂D-Phe CRF（（12-41））注入BNST后，条件性失败显著减少，但不注入CeA。在另一项实验中，给予单侧CeA损伤并将D-Phe CRF（（12-41））输注到对侧BNST中的仓鼠显示出比对照组明显更少的顺从行为。这些数据表明，CRF的行为在神经回路，包括杏仁核和BNST调节激动行为后的社会失败。
The authors investigated whether corticotropin-releasing factor (CRF) within the central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST) is a critical component of the neural circuitry mediating conditioned defeat. In this model, hamsters that have experienced social defeat subsequently display only submissive-defensive agonistic behavior instead of territorial aggression. Conditioned defeat was significantly reduced following infusion of the CRF receptor antagonist D-Phe CRF((12-41)) into the BNST but not into the CeA. In another experiment, hamsters given unilateral lesions of the CeA and infusions of D-Phe CRF((12-41)) into the contralateral BNST displayed significantly less submissive behavior than did controls. These data suggest that CRF acts within a neural circuit that includes the amygdala and the BNST to modulate agonistic behavior following social defeat.