Longitudinal Evaluation of the Occurrence of MRI-Detectable Bone Marrow Edema in Osteoarthritis of the Knee
Longitudinal Evaluation of the Occurrence of MRI-Detectable Bone Marrow Edema in Osteoarthritis of the Knee
复制标题
DOI：
10.1080/02841850802339413
复制
发表时间：
2008-01-01
期刊：
影响因子：
1.3
通讯作者：
Lang, P.
中科院分区：
文献类型：
--
作者：
Brem, M. H.;Schlechtweg, P. M.;Lang, P.
背景：骨髓水肿（BME）是一种可以通过磁共振成像（MRI）检测到的疾病，存在于骨关节炎（OA）的不同阶段。其发病机制尚不完全清楚。目的：探讨膝关节早期OA患者BME的纵向发生和持续性。材料与方法：对23例患者（女性8例，男性15例，平均年龄55.5 +/- 10.3岁）进行1.5T MR成像单元扫描（矢状脂肪抑制中重快速自旋回波，断面厚度4mm，交隙1mm，基质256x192，视野120mm）。所有23例患者在两个时间点（TPs）获得图像，12例患者在三个时间点获得图像。图像由两名读者独立评估；在图像分级差异进行审查和评估的共识。采用4点图像分级量表（无BME至重度BME）。评估了四个主要的解剖区域（股骨内侧、股骨外侧、胫骨内侧、胫骨外侧），并将其分为前、中、后区域。结果：23例患者在3个TPs均发现了105个BME区。在16个区域中，随着时间的推移，BME在同一位置保持一致，在7个区域中BME变大，在6个区域中BME变小，在16个位置中无法在后续mri中检测到BME。其中一例在TP2时BME较小，而在TP3时BME增大。在8个病例中，只有在最后一个时间点才能检测到BME。结论：BME不是一个静态现象，而是随时间变化的。应评估与体力活动和局部炎症反应的关系。
Background: Bone marrow edema (BME) is a condition detectable with magnetic resonance imaging (MRI) and is present in different stages of osteoarthritis (OA). Its pathogenesis is still not completely known.Purpose: To evaluate the longitudinal occurrence and persistence of BME in early OA of the knee.Material and Methods: Twenty-three patients (eight females, 15 males; mean age 55.5 +/- 10.3 years) were scanned with a 1.5T MR imaging unit (sagittal fat-suppressed intermediate-weighted fast spin echo; 4-mm section thickness, 1-mm intersection gap, 256x192 matrix, 120-mm field of view). Images were obtained in all 23 patients at two time points (TPs) and in 12 patients at three TPs. Images were evaluated by two readers independently; discrepancies in image grading were reviewed and evaluated in consensus. A four-point image-grading scale was used (absence of BME to severe BME). Four main anatomical regions were evaluated (medial femur, lateral femur, medial tibia, lateral tibia), which were subcategorized into anterior, central, and posterior regions.Results: One hundred five areas of BME in the 23 patients were found at all three TPs. In 16 areas, the BME was consistent at the same location over time, in seven locations the BME became larger, in six areas the BME became smaller, and in 16 locations it could not be detected in follow-up MRIs. In one case, the BME was smaller at TP2 but increased at TP3. In eight cases, only at the last time point could a BME be detected.Conclusion: BME is not a static phenomenon but changes over time. Correlation to physical activity and local inflammatory reaction should be evaluated.