Direct and indirect genetic effects of a social supergene
Direct and indirect genetic effects of a social supergene
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DOI：
10.1111/mec.16830
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发表时间：
2023-03-01
影响因子：
4.9
通讯作者：
Keller，Laurent
中科院分区：
文献类型：
--
作者：
Arsenault，Samuel V. V.;Riba-Grognuz，Oksana;Keller，Laurent
间接遗传效应描述了社会伙伴基因型组成差异导致的表型变异。这种效应代表了真社会生物环境变异的遗传来源，因为个体通常是由其兄弟姐妹抚养的。在红火蚁Solenopsis invicta，社会超基因表现出显着的间接遗传效应的工人调节殖民地女王数量，这样的基因型组成的工人在超基因决定是否殖民地包含一个或多个女王。我们评估了这种超基因对实验室饲养的工人大脑和腹部组织中基因表达的直接和间接遗传影响，并将其与先前发表的来自现场收集的繁殖前蚁后的数据进行了比较。我们发现，直接遗传效应引起更大的基因表达变化，并且在组织类型和种姓之间比间接遗传效应更一致。间接遗传效应影响许多位点的表达，但一般仅限于腹部组织。此外，间接的遗传效应只检测时，社会合作伙伴的基因型组成不同的整个发展和成年生活的重点工人，往往只有显着的相对宽松的统计截止。我们的研究提供了洞察社会超基因对基因调控动态的直接和间接的遗传影响，在一个复杂的社会组织和种姓。
Indirect genetic effects describe phenotypic variation that results from differences in the genotypic composition of social partners. Such effects represent heritable sources of environmental variation in eusocial organisms because individuals are typically reared by their siblings. In the fire antSolenopsis invicta, a social supergene exhibits striking indirect genetic effects on worker regulation of colony queen number, such that the genotypic composition of workers at the supergene determines whether colonies contain a single or multiple queens. We assessed the direct and indirect genetic effects of this supergene on gene expression in brains and abdominal tissues from laboratory‐reared workers and compared these with previously published data from field‐collected prereproductive queens. We found that direct genetic effects caused larger gene expression changes and were more consistent across tissue types and castes than indirect genetic effects. Indirect genetic effects influenced the expression of many loci but were generally restricted to the abdominal tissues. Further, indirect genetic effects were only detected when the genotypic composition of social partners differed throughout the development and adult life of focal workers, and were often only significant with relatively lenient statistical cutoffs. Our study provides insight into direct and indirect genetic effects of a social supergene on gene regulatory dynamics across tissues and castes in a complex society.