Relevance of liver fat to the impact of dietary extrinsic sugars on lipid metabolism
Relevance of liver fat to the impact of dietary extrinsic sugars on lipid metabolism
复制标题
DOI：
10.1017/s0029665115002050
复制
发表时间：
2015-08-01
影响因子：
7
通讯作者：
Griffin, B. A.
中科院分区：
文献类型：
--
作者：
Griffin, B. A.
与英国许多非传染性慢性疾病的死亡率下降相反，在过去的40年中，男性和女性的肝病死亡率呈指数级增长。这主要是因为过度饮酒，而且肥胖症的患病率增加，这与肝脏脂肪积累的早期病理学有关。超生理摄入含果糖的糖会对脂质代谢产生急性不良影响，并提供过量的能量，增加体重和脂肪在脂肪组织以外的部位（包括肝脏）的沉积。本文综述了肝脏脂肪的可变代谢来源，以及餐后脂质代谢在这方面的重要性。超生理摄入糖的影响也被认为是在真实的世界的背景下，并建立了糖对心脏代谢危险因素的不利影响的阈值。审查的结论是，虽然英国的平均糖摄入量福尔斯远低于这一临界阈值，但成年人，特别是青少年的摄入量可能会引起关注。还有证据表明，部分通过餐后脂血症的清除受损而获得的肝脏脂肪增加，可以增加所有年龄段对糖的不良影响的敏感性。
In contrast to the decline in mortality from many non-infectious, chronic diseases in the UK, death from liver disease has increased exponentially in men and women over the past 40 years. This is primarily because of the over consumption of alcohol, but also the increased prevalence of obesity, which is linked to early pathology through the accumulation of liver fat. Supra-physiological intakes of fructose-containing sugar can produce acute, adverse effects on lipid metabolism, and deliver excess energy that increases bodyweight and the deposition of fat in sites other than adipose tissue, including the liver. This review addresses the variable metabolic origins of liver fat, and the key importance of postprandial lipid metabolism in this respect. The effects of supra-physiological intakes of sugar are also considered in context of the real world and established threshold for the adverse effects of sugar on cardio-metabolic risk factors. The review concludes that while the average intake of sugar in the UK falls well below this critical threshold, intakes in subgroups of adults, and especially adolescents, may be cause for concern. There is also evidence to suggest that raised liver fat, acquired, in part, through an impaired removal of postprandial lipaemia, can increase sensitivity to the adverse effects of sugar at all ages.