Systemic effects of fractionated, whole-brain irradiation in young adult and aging rats.
Systemic effects of fractionated, whole-brain irradiation in young adult and aging rats.
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DOI：
10.1667/rr3313.1
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发表时间：
2013-09
影响因子：
3.4
通讯作者：
Riddle DR
中科院分区：
文献类型：
--
作者：
Forbes ME;Paitsel M;Bourland JD;Riddle DR
颅脑放射治疗是治疗原发性脑肿瘤和脑转移瘤的一种重要而有效的方法。不幸的是，大多数接受治疗并存活几个月以上的患者由于辐射引起的正常组织损伤而出现神经和认知问题。这些认知缺陷背后的神经生物学机制在很大程度上仍然是未知的，也没有有效的治疗方法来预防或改善它们;因此，在动物模型中进行临床前研究是一个显着和持续的需求。几个实验室的研究表明，啮齿类动物头部照射后发生了神经生物学变化。然而，迄今为止，在动物模型中的实验研究包括很少的全身影响的颅照射的评估，尽管从临床证据表明，颅照射的结果在整个身体的变化和认识，全身反应可能会影响神经和认知缺陷的发展。本研究评价了成年大鼠临床相关分次全脑照射的全身效应，并证明了对生长激素/胰岛素样生长因子-I轴的影响，这可能有助于神经变化的发展。这些和其他系统反应是重要的考虑正在进行的努力，以了解辐射诱导的正常组织损伤的机制。
Cranial irradiation is a critical and effective treatment for primary brain tumors and metastases. Unfortunately, most patients who are treated and survive for more than a few months develop neural and cognitive problems as the result of radiation-induced normal tissue injury. The neurobiological mechanisms underlying these cognitive deficits remain largely unknown and there are no validated treatments to prevent or ameliorate them; thus, there is a significant and continuing need for preclinical studies in animal models. Investigations from several laboratories have demonstrated neurobiological changes after cranial irradiation in rodents. To date, however, experimental studies in animal models have included little assessment of the systemic effects of cranial irradiation, despite evidence from the clinic that cranial irradiation results in changes throughout the body and recognition that systemic responses may influence the development of neural and cognitive deficits. This study evaluated systemic effects of clinically relevant, fractionated whole-brain irradiation in adult rats and demonstrates effects on the growth hormone/insulin-like growth factor-I axis, which may contribute to the development of neural changes. These and other systemic responses are important to consider in ongoing efforts to understand the mechanisms of radiation-induced normal tissue injury.