Selectivity for large nonmanipulable objects in scene-selective visual cortex does not require visual experience
Selectivity for large nonmanipulable objects in scene-selective visual cortex does not require visual experience
复制标题
场景选择性视觉皮层对大型不可操作物体的选择性不需要视觉经验
DOI：
10.1016/j.neuroimage.2013.04.051
复制
发表时间：
2013-10-01
期刊：
影响因子：
5.7
通讯作者：
Bi, Yanchao
中科院分区：
文献类型：
--
作者：
He, Chenxi;Peelen, Marius V.;Bi, Yanchao
确定腹侧颞叶皮层（VTC）中对象表征组织的原则仍然难以捉摸。在这里，我们专注于海马旁位置区（PPA），在内侧VTC，已被证明有选择性地响应场景的图片的区域。最近的研究进一步观察到，这个区域也显示出相对于其他物体而言对大型不可操纵物体的偏好，这可能反映了大型物体对导航的适用性。这种选择性背后的机制仍然知之甚少。我们检查了PPA选择性对视觉体验的要求程度。14名先天失明和视力匹配的参与者进行了测试的听觉大小判断实验，涉及大型不可操作的对象，小物体（工具），和动物。视力正常的参与者还参加了一个观看图片的实验。复制以前的工作，我们发现，PPA选择性地响应大型不可操纵的对象，相对于工具和动物，在视力组观看图片。重要的是，这种选择性也在听觉实验中观察到，无论是视力正常的还是先天性失明的。在这两组中，选择性的大型不可操纵的对象，另外观察到在后复合体（RSC）和枕横沟（TOS），区域先前涉及场景感知和导航。最后，在这两个群体中，PPA表现出与TOS和RSC的静息状态功能连接。这些结果提供了新的证据，证明PPA中的大对象选择性以及PPA与其他导航相关区域之间的内在连接性不需要视觉体验。更一般地说，他们表明，组织的对象表示在VTC可以发展，至少部分，没有视觉经验。(c)2013 Elsevier Inc. All rights reserved.
The principles that determine the organization of object representations in ventral temporal cortex (VTC) remain elusive. Here, we focus on the parahippocampal place area (PPA), a region in medial VTC that has been shown to respond selectively to pictures of scenes. Recent studies further observed that this region also shows a preference for large nonmanipulable objects relative to other objects, which might reflect the suitability of large objects for navigation. The mechanisms underlying this selectivity remain poorly understood. We examined the extent to which PPA selectivity requires visual experience. Fourteen congenitally blind and matched sighted participants were tested on an auditory size judgment experiment involving large nonmanipulable objects, small objects (tools), and animals. Sighted participants additionally participated in a picture-viewing experiment. Replicating previous work, we found that the PPA responded selectively to large nonmanipulable objects, relative to tools and animals, in the sighted group viewing pictures. Importantly, this selectivity was also observed in the auditory experiment in both sighted and congenitally blind groups. In both groups, selectivity for large nonmanipulable objects was additionally observed in the retrosplenial complex (RSC) and the transverse occipital sulcus (TOS), regions previously implicated in scene perception and navigation. Finally, in both groups the PPA showed resting-state functional connectivity with TOS and RSC. These results provide new evidence that large object selectivity in PPA, and the intrinsic connectivity between PPA and other navigation-relevant regions, do not require visual experience. More generally, they show that the organization of object representations in VTC can develop, at least partly, without visual experience. (c) 2013 Elsevier Inc. All rights reserved.