Suppression of amphetamine-induced EEG arousal in the hippocampus of haloperidol-treated rabbits.
Suppression of amphetamine-induced EEG arousal in the hippocampus of haloperidol-treated rabbits.
复制标题
氟哌啶醇治疗兔海马区苯丙胺诱导的脑电图唤醒的抑制。
DOI：
10.1159/000117837
复制
发表时间：
1981
影响因子：
3.2
通讯作者：
Fieve,RR
中科院分区：
文献类型：
--
作者：
Budek,M;Barkai,AI;Brown,DL;Fieve,RR
研究了氟哌啶醇慢性治疗前、中、后给药d-安非他明对家兔海马脑电活动的影响。脑电数据的交叉零分析显示，氟哌啶醇慢性治疗（3mg / kg/天，每次1次，持续9天）可减弱安非他明引起的海马θ节律升高。氟哌啶醇停药30天后，安非他明对θ活动的增加完全恢复。此外，氟哌啶醇降低了4只动物中3只自发θ节律的发生率。提示苯丙胺类药物对海马θ波的增强部分是由多巴胺能机制介导的，而多巴胺能机制易受氟哌啶醇的影响。
Changes of hippocampal EEG activity resulting from administration ofd-amphetamine were investigated in rabbits before, during and after chronic treatment with haloperidol. Cross-zero analysis of EEG data showed that chronic treatment with haloperidol (3 mg/ kg/day, i.p. for 9 days) attenuated the amphetamine-induced increase in hippocampal theta rhythm. The increase of theta activity by amphetamine was fully restored 30 days after withdrawal of haloperidol. Further, haloperidol reduced the incidence of spontaneous theta rhythm in 3 out of 4 animals. It is suggested that the enhancement of hippocampal theta byd-amphetamine is mediated in part by dopaminergic mechanisms which are susceptible to the action of haloperidol.