A prospective follow-up study of pediatric bipolar disorder in boys with attention-deficit/hyperactivity disorder
A prospective follow-up study of pediatric bipolar disorder in boys with attention-deficit/hyperactivity disorder
复制标题
DOI：
10.1016/j.jad.2004.05.012
复制
发表时间：
2004-10-01
影响因子：
6.6
通讯作者：
Wozniak, J
中科院分区：
文献类型：
--
作者：
Biederman, J;Mick, E;Wozniak, J
目的：研究儿童双相情感障碍的持续和缓解模式，包括双相情感障碍症状缓解的综合征，症状，功能和情感定义，纵向样本中ADHD儿童共病双相情感障碍。方法：对128名ADHD男孩进行为期1年和4年的随访，通过结构化的诊断访谈来评估精神合并症的持久性。通过计算在1年或4年随访评估中报告的从发病年龄到缓解年龄的时间来估计双相情感障碍的病程和持续时间。结果：22名（17%，流行病例）受试者在基线评估时符合双相情感障碍的标准。这些受试者的平均年龄在基线时为10.5+/-3.0岁（范围：6至17岁），随访时为14.4+/-3.1岁。缓解率在很大程度上取决于所使用的定义。功能缓解率最低，症状缓解率最高。然而，不管使用什么定义，这种疾病都是慢性的，并且持续多年。局限性：由于样本量和缺乏情绪症状评定量表，这些数据应被视为初步数据。结论：在整个评估期间，不到20%的受试者达到功能缓解或心境愉悦，这进一步证明了儿童双相情感障碍是一种预后不良的慢性情绪障碍。(C) 2004 Elsevier B.V.版权所有
Objective: To examine patterns of persistence and remission in pediatric bipolar disorder attending to syndromatic, symptomatic, functional and affective definitions of remission of bipolar symptomatology in a longitudinal sample of ADHD children with comorbid bipolar disorder.Methods: ADHD boys (128) were followed over 1- and 4-year follow-up assessments with structured diagnostic interviews to assess the persistence of psychiatric comorbidity. The course and duration of bipolar disorder was estimated by calculating the time from age at onset and the age at remission reported at either the 1- or 4-year follow-up assessments.Results: Twenty-two (17%, Prevalent Cases) subjects met criteria for bipolar disorder at the baseline assessment. The average age of these subjects was 10.5+/-3.0 (range: 6 to 17 years) at baseline and 14.4+/-3.1 years of age at follow-up. The rate of remission was heavily dependent on the definition used. The rate of functional remission was the lowest and the rate of syndromatic remission was the highest. Regardless of the definition used, however, the disorder was chronic and lasted many years.Limitations: These data should be considered preliminary due to the sample size and the absence of mood symptom rating scales.Conclusions: That less than 20% of subjects attained functional remission or euthymia over the entire time period evaluated provides further evidence that pediatric bipolar disorder is a chronic mood disorder with a poor prognosis. (C) 2004 Elsevier B.V. All rights reserved.